De Lorenzo A, Ceccanti M, Romeo M, Pisculli M, Di Giovanni M G, Lais A, Assogna G, Valgiusti F C
Int J Clin Pharmacol Res. 1986;6(1):77-9.
Ketanserin is a pure antagonist of serotonin S2-receptors, in blood vessels, platelets and bronchial tissue. Ketanserin has been suggested as hypotensive drug in man, but it shows as well a specific activity on platelet aggregation. An increased incidence of hypertension, of unknown origin, has been found in patients with chronic alcoholism: hypotheses have been made upon an increased incretion of catecholamines and a greater sensitivity of blood vessels' receptors to their action. The data from the present study of eleven patients show that these subjects had an increased platelet activity and ketanserin administration was effective in allowing both the blood pressure levels and platelet activity to resume their normal range. This drug is thus suggested, for its pharmacological properties, as an elective medication for hypertensive patients with chronic alcoholism.
酮色林是一种血清素S2受体的纯拮抗剂，作用于血管、血小板和支气管组织。酮色林已被提议作为人类的降压药物，但它对血小板聚集也有特定活性。在慢性酒精中毒患者中发现了不明原因的高血压发病率增加：有人提出了儿茶酚胺分泌增加以及血管受体对其作用敏感性增强的假说。本研究对11名患者的数据表明，这些受试者的血小板活性增加，给予酮色林可有效使血压水平和血小板活性恢复正常范围。因此，鉴于其药理特性，这种药物被建议作为慢性酒精中毒高血压患者的首选药物。
