过氧化物酶 1 抑制细胞迁移和侵袭，参与肝癌复发。

Peroxiredoxin 1, restraining cell migration and invasion, is involved in hepatocellular carcinoma recurrence.

机构信息

Department of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai, China.

Francis Family Liver Clinic, University of Toronto & University Health Network, Toronto, Canada.

出版信息

J Dig Dis. 2018 Mar;19(3):155-169. doi: 10.1111/1751-2980.12580.

DOI:10.1111/1751-2980.12580

PMID:29377617

Abstract

OBJECTIVE

Hepatocellular carcinoma (HCC) is a high-burden disease. Peroxiredoxin 1 (PRDX1) is a member of the peroxiredoxin family of antioxidant enzymes. The aim of this study was to assess the value of PRDX1 for predicting HCC recurrence after curative resection and to explore the role of PRDX1 in HCC cell migration and invasion.

METHODS

Data of patients with HCC who had undergone complete resection between 2002 and 2006 were collected. Immunohistochemical detection of PRDX1 in HCC tissue and adjacent non-cancerous tissue was conducted. Kaplan-Meier survival estimate and log-rank test were used to assess the relationship between PRDX1 expression and prognostic significance. HCC cell migration and invasion together with the interaction between PRDX1 and ubiquitin C-terminal hydrolase 37 (UCH37) were studied in vitro.

RESULTS

PRDX1 was expressed at lower levels in HCC tissues than in adjacent non-cancerous tissues, and PRDX1 was found to be an independent risk factor for disease-free survival and overall survival. PRDX1 restrained cell migration and invasion in vitro. PRDX1 was found to interact with UCH37 to affect HCC cell migration and invasion.

CONCLUSION

PRDX1 restrains cell migration and invasion in HCC cell lines and that may be involved in a UCH37-relevant pathway, suggesting that PRDX1 may be a new marker for HCC recurrence after surgery.

摘要

目的

肝细胞癌（HCC）是一种高负担疾病。过氧化物还原酶 1（PRDX1）是抗氧化酶过氧化物还原酶家族的一员。本研究旨在评估 PRDX1 预测根治性切除术后 HCC 复发的价值，并探讨 PRDX1 在 HCC 细胞迁移和侵袭中的作用。

方法

收集 2002 年至 2006 年间接受完全切除术的 HCC 患者的数据。对 HCC 组织和相邻非癌组织中的 PRDX1 进行免疫组织化学检测。采用 Kaplan-Meier 生存估计和对数秩检验评估 PRDX1 表达与预后意义之间的关系。在体外研究 HCC 细胞迁移和侵袭以及 PRDX1 与泛素 C 末端水解酶 37（UCH37）之间的相互作用。