Weidmann P, Hellmueller B, Uehlinger D E, Lang R E, Gnaedinger M P, Hasler L, Shaw S, Bachmann C
J Clin Endocrinol Metab. 1986 May;62(5):1027-36. doi: 10.1210/jcem-62-5-1027.
Endogenous plasma concentrations of human atrial natriuretic peptide (alpha hANP) as well as effects of synthetic alpha hANP on some cardiovascular, endocrine, and renal excretory parameters were investigated in 10 normal subjects during sodium (Na+) intakes of 17, 140, and 310 mmol/day, respectively. Plasma hANP was slightly but not significantly higher after 5 days of normal or high sodium intake than after 5 days of low sodium intake [54 +/- 13, 46 +/- 8, and 37 +/- 5 (mean +/- SEM) pg/ml, respectively]. alpha hANP infused at 0.1 microgram/kg X min during all Na+ intakes produced a similar fall in diastolic blood pressure (P less than 0.001) and rise in heart rate (P less than 0.001), a comparable percent increase in plasma norepinephrine (P less than 0.001), and a reduction in plasma cortisol and aldosterone (P less than 0.01-0.001) despite raised renin activity (P less than 0.05-0.001) and unchanged plasma electrolytes. alpha hANP-induced plasma volume contraction, diuresis, and natriuresis were greater during high than low Na+ intake (P less than 0.01-0.001). Therefore, in normal man different Na+ intakes are accompanied by marked modifications in renal excretory responsiveness to alpha hANP. Regardless of sodium intake, alpha hANP can promote BP reduction and hemoconcentration, elicit reflex (?) sympathetic activation, and depress basal circulating aldosterone and cortisol levels in the face of an activated renin system.
在10名正常受试者中，分别研究了每日钠（Na +）摄入量为17、140和310 mmol时，人心房利钠肽（α-hANP）的内源性血浆浓度以及合成α-hANP对一些心血管、内分泌和肾脏排泄参数的影响。正常或高钠摄入5天后的血浆hANP略高于低钠摄入5天后，但差异无统计学意义[分别为54±13、46±8和37±5（平均值±标准误）pg/ml]。在所有Na +摄入量期间，以0.1μg/kg×min的速度输注α-hANP，舒张压均出现相似程度的下降（P<0.001），心率升高（P<0.001），血浆去甲肾上腺素百分比升高程度相当（P<0.001），血浆皮质醇和醛固酮降低（P<0.01-0.001），尽管肾素活性升高（P<0.05-0.001）且血浆电解质未改变。高Na +摄入时α-hANP诱导的血浆容量收缩、利尿和排钠作用比低Na +摄入时更大（P<0.01-0.001）。因此，在正常男性中，不同的Na +摄入量伴随着肾脏对α-hANP排泄反应性的显著改变。无论钠摄入量如何，α-hANP都可以促进血压降低和血液浓缩，引发反射性（？）交感神经激活，并在肾素系统激活的情况下降低基础循环醛固酮和皮质醇水平。
