Rheumatology, Allergology and Clinical Immunology, Department of Medicina dei Sistemi, University of Rome Tor Vergata, Rome, Italy.
Rheumatology, Department of Internal Medicine, Sapienza University of Rome, Rome, Italy.
Autoimmun Rev. 2018 Mar;17(3):276-283. doi: 10.1016/j.autrev.2018.01.002. Epub 2018 Feb 3.
Psoriatic arthritis (PsA) is a chronic inflammatory joint disease, seen in combination with psoriasis. Both genetic and environmental factors are responsible for the development of PsA, however little is known about the different weight of these two distinctive components in the pathogenesis of the disease. Genomic variability in PsA is associated with the disease and/or some peculiar clinical phenotypes. Candidate genes involved are crucial in inflammation, immune system, and epithelial permeability. Moreover, the genesis and regulation of inflammation are influenced by the composition of the human intestinal microbiome that is able to modulate both mucosal and systemic immune system. It is possible that pro-inflammatory responses initiated in gut mucosa could contribute to the induction and progression of autoimmune conditions. Given such premises, the aim of this review is to summarize immune-mediated response and specific bacterial changes in the composition of fecal microbiota in PsA patients and to analyze the relationships between bacterial changes, immune system, and host genetic background.
银屑病关节炎（PsA）是一种慢性炎症性关节疾病，常与银屑病同时发生。遗传和环境因素都与 PsA 的发生有关，但对于疾病发病机制中这两个不同因素的相对重要性知之甚少。PsA 中的基因组变异性与疾病和/或一些特殊的临床表型有关。候选基因在炎症、免疫系统和上皮通透性中起着关键作用。此外，炎症的发生和调节受人类肠道微生物组的组成影响，它能够调节黏膜和系统免疫系统。在肠道黏膜中引发的促炎反应可能有助于自身免疫性疾病的诱导和进展。基于这些前提，本综述的目的是总结 PsA 患者粪便微生物群组成中免疫介导的反应和特定细菌变化，并分析细菌变化、免疫系统和宿主遗传背景之间的关系。
