Department of Urology, Zhongshan Hospital, Fudan University, Shanghai Key Laboratory of Organ Transplantation, 180 Fenglin Road, Shanghai, 200032, China.
Department of Intensive Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
J Transl Med. 2018 Jan 29;16(1):19. doi: 10.1186/s12967-018-1395-9.
Myeloid-derived suppressor cells (MDSCs) are a series of innate cells that play a significant role in inhibiting T cell-related responses. This heterogeneous population of immature cells is involved in tumor immunity. Recently, the function and importance of MDSCs in transplantation have garnered the attention of scientists and have become an important focus of transplantation immunology research because MDSCs play a key role in establishing immune tolerance in transplantation. In this review, we summarize recent studies of MDSCs in different types of transplantation. We also focus on the influence of immunosuppressive drugs on MDSCs as well as future obstacles and research directions in this field.
髓系来源的抑制性细胞（MDSCs）是一系列在抑制 T 细胞相关反应中起重要作用的先天细胞。这种异质性的未成熟细胞群参与肿瘤免疫。最近，MDSCs 在移植中的功能和重要性引起了科学家的关注，并成为移植免疫学研究的一个重要焦点，因为 MDSCs 在移植中建立免疫耐受方面发挥着关键作用。在这篇综述中，我们总结了 MDSCs 在不同类型移植中的最新研究。我们还重点关注了免疫抑制药物对 MDSCs 的影响，以及该领域未来的障碍和研究方向。
