Al-Enazi Nouf M, Awaad Amani S, Alqasoumi Saleh I, Alwethairi Metab F
Biology Department, College of Science and Humanity Studies, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia.
Pharmacognosy Department, College of Pharmacy, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia.
Saudi Pharm J. 2018 Jan;26(1):25-32. doi: 10.1016/j.jsps.2017.11.003. Epub 2017 Nov 13.
The biological activities; antimicrobial, antioxidant and anticancer, of the red algae and were determined. The total ethanol, lipoidal matters, chloroform, n-butanol, aqueous extracts and powder of both algae showed and bacterial and antifungal activities. However, the chloroform extract of showed antibacterial activity against (24 mm, 0.15 mg/ml) higher than gentamycin (23 mm, 0.49 mg/ml). Moreover, the total ethanol, lipoidal matter and chloroform extracts showed antifungal activity (21, 22 and 25 mm, 1.25, 0.312 and 0.156 mg/ml) similar to the antibiotic Ketoconazole activity (23, 24 and 27 mm, 1.25, 0.312 and 0.156 mg/ml) against , and , respectively. A good antioxidant activity (80.96%, IC = 27.8 µg/ml) was provided by . The anticancer activity results revealed that the lipoidal matters of and possessed antitumor activity (IC = 15 ± 1.7 and 21.2 ± 1.6, respectively) against lung carcinoma (A-549) better than vinblastine sulfate (IC = 24.6 ± 0.7). Although, the lipoidal matters of and antitumor activity against cervical carcinoma (HeLa) and intestinal carcinoma (CACO-2) (IC = 10.2 ± 0.6 and 12.2 ± 0.6, respectively) preferable than vinblastine sulfate (IC = 59.7 ± 2.1 and 30.3 ± 1.4, respectively).
测定了红藻的生物活性,包括抗菌、抗氧化和抗癌活性。两种藻类的总乙醇提取物、脂质物质、氯仿提取物、正丁醇提取物、水提取物及藻粉均表现出抗菌和抗真菌活性。然而,[藻类名称2]的氯仿提取物对[细菌名称]表现出抗菌活性(抑菌圈直径24毫米,浓度0.15毫克/毫升),高于庆大霉素(抑菌圈直径23毫米,浓度0.49毫克/毫升)。此外,总乙醇提取物、脂质物质提取物和氯仿提取物表现出抗真菌活性(抑菌圈直径分别为21、22和25毫米,浓度分别为1.25、0.312和0.156毫克/毫升),与抗生素酮康唑对[真菌名称1]、[真菌名称2]和[真菌名称3]的活性(抑菌圈直径分别为23、24和27毫米,浓度分别为1.25、0.312和0.156毫克/毫升)相似。[藻类名称1]具有良好的抗氧化活性(抗氧化率80.96%,半数抑制浓度IC₅₀ = 27.8微克/毫升)。抗癌活性结果显示,[藻类名称1]和[藻类名称2]的脂质物质对肺癌(A - 549)具有抗肿瘤活性(半数抑制浓度IC₅₀分别为15 ± 1.7和21.2 ± 1.6),优于硫酸长春碱(半数抑制浓度IC₅₀ = 24.6 ± 0.7)。尽管如此,[藻类名称1]和[藻类名称2]的脂质物质对子宫颈癌(HeLa)和结肠癌(CACO - 2)的抗肿瘤活性(半数抑制浓度IC₅₀分别为10.2 ± 0.6和12.2 ± 0.6)优于硫酸长春碱(半数抑制浓度IC₅₀分别为59.7 ± 2.1和30.3 ±