Tsujitani M, Okabe E, Ito H
Jpn J Pharmacol. 1986 Jan;40(1):135-41. doi: 10.1254/jjp.40.135.
Effect of potassium gluconate (K-GL) on K+ uptake of rat erythrocytes was investigated. K-GL produced a significant increase in active K+ transport of Na+-rich erythrocytes, while Na+,K+-ATPase activity of hemoglobin-free ghosts without a glycolytic system was unaffected. When the experiment was carried out in intact erythrocytes, K-GL increased the lactate production and ATP content, and it promoted the methemoglobin reduction rate. In Na+-rich erythrocytes, the glycolysis inhibitors which produced a marked reduction in lactate content abolished the K-GL-induced increase in K+ and ATP content without affecting the KCl-induced increase. These results suggest that K-GL enhances K+ transport of erythrocytes through acceleration of glycolytic process.
研究了葡萄糖酸钾（K-GL）对大鼠红细胞钾离子摄取的影响。K-GL使富含钠离子的红细胞的活性钾离子转运显著增加，而在没有糖酵解系统的无血红蛋白血影中，钠钾-ATP酶活性未受影响。当在完整红细胞中进行实验时，K-GL增加了乳酸生成和ATP含量，并促进了高铁血红蛋白还原率。在富含钠离子的红细胞中，使乳酸含量显著降低的糖酵解抑制剂消除了K-GL诱导的钾离子和ATP含量增加，而不影响氯化钾诱导的增加。这些结果表明，K-GL通过加速糖酵解过程增强红细胞的钾离子转运。
