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用于DNA序列聚类的基因组信号处理

Genomic signal processing for DNA sequence clustering.

作者信息

Mendizabal-Ruiz Gerardo, Román-Godínez Israel, Torres-Ramos Sulema, Salido-Ruiz Ricardo A, Vélez-Pérez Hugo, Morales J Alejandro

机构信息

Departamento de Ciencias Computacionales, Universidad de Guadalajara, Guadalajara, Mexico.

出版信息

PeerJ. 2018 Jan 24;6:e4264. doi: 10.7717/peerj.4264. eCollection 2018.

Abstract

Genomic signal processing (GSP) methods which convert DNA data to numerical values have recently been proposed, which would offer the opportunity of employing existing digital signal processing methods for genomic data. One of the most used methods for exploring data is cluster analysis which refers to the unsupervised classification of patterns in data. In this paper, we propose a novel approach for performing cluster analysis of DNA sequences that is based on the use of GSP methods and the K-means algorithm. We also propose a visualization method that facilitates the easy inspection and analysis of the results and possible hidden behaviors. Our results support the feasibility of employing the proposed method to find and easily visualize interesting features of sets of DNA data.

摘要

最近有人提出了将DNA数据转换为数值的基因组信号处理(GSP)方法,这将为对基因组数据应用现有的数字信号处理方法提供机会。数据探索中最常用的方法之一是聚类分析,它指的是对数据中的模式进行无监督分类。在本文中,我们提出了一种基于GSP方法和K均值算法对DNA序列进行聚类分析的新方法。我们还提出了一种可视化方法,便于对结果以及可能的隐藏行为进行轻松检查和分析。我们的结果支持了采用所提出的方法来查找并轻松可视化DNA数据集有趣特征的可行性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8c4/5786891/347bc346cc74/peerj-06-4264-g001.jpg

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