Hilleman M R
Med J Aust. 1986 Mar 31;144(7):360-4. doi: 10.5694/j.1326-5377.1986.tb115921.x.
Vaccinology, while affording great opportunities in the prevention of infectious diseases, also poses the problem of stretching the possible beyond the practicable. Politics, economics, and technology all come together at the point of resource allocation. It is important to maintain a balance between expenditure for the development of vaccines and for the application of vaccines if maximal good is to be achieved in this new era of technical opportunity. A promising approach is to include in single "polytopic" vaccines the largest number of immunogenic epitopes for the greatest number of important diseases.
疫苗学在预防传染病方面提供了巨大机遇，但也带来了将可能性扩展到不切实际范围的问题。政治、经济和技术在资源分配这一点上交织在一起。如果要在这个技术机遇的新时代实现最大利益，在疫苗研发支出和疫苗应用支出之间保持平衡很重要。一种有前景的方法是在单一的“多靶点”疫苗中纳入针对最多重要疾病的最大数量的免疫原性表位。
