Key Laboratory of Organo-pharmaceutical Chemistry of Jiangxi province, Gannan Normal University, Ganzhou, 341000, China.
Org Biomol Chem. 2018 Feb 21;16(8):1247-1251. doi: 10.1039/c7ob03113k.
An efficient synthesis of a variety of pyridyl benzamides from 2-aminopyridines and nitroolefins is described. This rare-earth-metal-catalyzed reaction provides the corresponding products with broad substrate scope in moderate to excellent yields, in the absence of additives and external oxidants. Water is used as the source of the carbonyl oxygen atom in pyridyl benzamides. Furthermore, 2-substituted oxazolo[4,5-b]pyridines are formed in good yields under the standard conditions when 2-aminopyridin-3-ols are used as the substrates.
描述了一种从 2-氨基吡啶和硝基烯烃高效合成各种吡啶基苯甲酰胺的方法。在没有添加剂和外部氧化剂的情况下，该稀土金属催化反应以中等至优异的收率提供了具有广泛底物范围的相应产物。吡啶基苯甲酰胺中的羰基氧原子来自于水。此外，当使用 2-氨基吡啶-3-醇作为底物时，在标准条件下可以很好地得到 2-取代的噁唑并[4,5-b]吡啶。
