抗金黄色葡萄球菌小皮伞素来源于小皮伞菌的子实体。
Anti-Staphylococcal Calopins from Fruiting Bodies of Caloboletus radicans.
机构信息
Faculty of Biology and Chemistry, Institute for Organic and Analytical Chemistry, University of Bremen , NW2C, Leobener Straße 7, D-28359 Bremen, Germany.
Department of Pharmacy, Manarat International University , Gulshan-2, Dhaka-1212, Bangladesh.
出版信息
J Nat Prod. 2018 Feb 23;81(2):400-404. doi: 10.1021/acs.jnatprod.7b00525. Epub 2018 Jan 30.
Three new and seven known calopins were isolated from Caloboletus radicans. The structures of the new cyclocalopins, 8-deacetylcyclocalopin B (1), cyclocalopin A-15-ol (2), and 12,15-dimethoxycyclocalopin A (3), were mainly elucidated by NMR and MS data analysis. The stereochemistry of 1-3 was assigned based on NOE correlations and coupling constants and by comparison of their CD spectra with those of similar known calopins. While 1-10 were inactive against two cancer cell lines, they displayed anti-staphylococcal activity against methicillin-resistant Staphylococcus aureus strains (MRSA) with MIC values of 16-256 μg/mL. Moreover, some calopins were active against the fish pathogen Enterococcus faecalis F1B1.
从红绒盖牛肝菌中分离得到了 3 个新的和 7 个已知的环钙蛋白。新的环钙蛋白 8-去乙酰基环钙蛋白 B（1）、环钙蛋白 A-15-醇（2）和 12,15-二甲氧基环钙蛋白 A（3）的结构主要通过 NMR 和 MS 数据分析进行了阐明。基于 NOE 相关和偶合常数以及与类似已知环钙蛋白的 CD 光谱的比较，确定了 1-3 的立体化学。虽然 1-10 对两种癌细胞系没有活性，但它们对耐甲氧西林金黄色葡萄球菌（MRSA）菌株表现出抗葡萄球菌活性，MIC 值为 16-256μg/mL。此外，一些环钙蛋白对鱼类病原体粪肠球菌 F1B1 具有活性。
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