Thomas L, Krifi S, Fay D, Saignavong S, Delubac G, Moraillon X, Demingeon G
Presse Med. 1986 Feb 15;15(6):241-5.
An 18-year old girl developed acute fulminating meningococcaemia with meningitis, coma, shock, coagulation disorders and extensive purpura. Measurement of intracranial pressure showed severe intracranial hypertension. After medical treatment of shock and intracranial hypertension had failed, external drainage of the cerebrospinal fluid was performed in the lumbar region, using a 16 G silicone catheter. This controlled the intracranial hypertension; also the state of shock regressed and the patient became fully conscious. The lumbar drainage was maintained for 12 days during which 3180 ml of blood-stained cerebrospinal fluid were evacuated. The fluid was sterilized by antibiotics as early as the 1st day of the disease, but it remained positive for bacterial antigen up to the 9th day. Cure was obtained without neurological sequelae, thanks to the lumber drainage which controlled intracranial hypertension and removed large amounts of microbial toxins.
一名18岁女孩患上急性暴发性脑膜炎球菌血症，伴有脑膜炎、昏迷、休克、凝血功能障碍和广泛紫癜。颅内压测量显示存在严重的颅内高压。在抗休克和治疗颅内高压的药物治疗失败后，使用16G硅胶导管在腰椎区域进行了脑脊液外引流。这控制了颅内高压；休克状态也得到缓解，患者完全清醒。腰椎引流维持了12天，在此期间引出了3180毫升血性脑脊液。早在疾病第1天，脑脊液就用抗生素进行了消毒，但直到第9天细菌抗原检测仍为阳性。由于腰椎引流控制了颅内高压并清除了大量微生物毒素，患者得以治愈且无神经后遗症。
