Suppr超能文献

[乳腺癌的保守治疗。10年后的结果]

[Conservative treatment of breast cancer. Results after 10 years].

作者信息

Pierquin B, Raynal M, Otmezguine Y, Mazeron J J, Martin M, Germain A, Julien M, Marinello G, Le Bourgeois J P, Calitchi E

出版信息

Presse Med. 1986 Feb 22;15(8):375-7.

PMID:2938155
Abstract

Between 1961 and 1975, 300 women with cancer of the breast (T1:72; T2:167; T3:61) were treated conservatively with radiotherapy alone (T3) or with partial or predominant radiotherapy combined with tumorectomy without axillary dissection (T1 or T2). The results, normalized at 10 years, confirmed that the survival rate (crude or NED) was exactly the same as with other conservative treatments or mutilating surgical treatments. Relapses were few (8%) in T1 cases and acceptable in T2 and T3 cases (13% and 18% respectively); in almost every patient they were amenable to surgery, with good local postoperative course. The prevalence of metastases was directly proportional to the size of the tumour; it was neither more nor less frequent than after radical surgery. Complications were rare and not very severe. Cosmetic results were either excellent (T1) or satisfactory (T2, T3). Finally, the proportions of breasts preserved at 10 years among patients alive and NED was very high, ranging from 96% (T1) to 91% (T2) and 87% (T3). These good results were associated with the possibility of high dosage additional endocurietherapy of the tumoral area with iridium 192, particularly in extensive forms where tumorectomy was cosmetically precluded. Since 1975, we have been using the conservative treatment in closer association with non mutilating surgery.

摘要

1961年至1975年间,300例乳腺癌患者(T1期:72例;T2期:167例;T3期:61例)接受了单纯放疗(T3期)或部分放疗或主要放疗联合肿瘤切除且未进行腋窝清扫术(T1或T2期)的保守治疗。10年标准化后的结果证实,生存率(粗生存率或无疾病证据生存率)与其他保守治疗或根治性手术治疗完全相同。T1期复发较少(8%),T2期和T3期复发率可接受(分别为13%和18%);几乎所有患者的复发都可通过手术治疗,术后局部恢复良好。转移的发生率与肿瘤大小成正比;其发生率与根治性手术后相比并无差异。并发症罕见且不太严重。美容效果在T1期为极佳,在T2期和T3期为满意。最后,存活且无疾病证据的患者中10年后保留乳房的比例非常高,从T1期的96%到T2期的91%和T3期的87%不等。这些良好的结果与使用铱192对肿瘤区域进行高剂量额外近距离放疗的可能性有关,特别是在因美容原因无法进行肿瘤切除的广泛型病例中。自1975年以来,我们一直在将保守治疗与非根治性手术更紧密地结合使用。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验