Czernichow P, Lerebours E, Colin R
Presse Med. 1986 Feb 22;15(8):387-91.
In view of the poor prognosis of pancreatic cancer, improvements in our knowledge of its epidemiology are desirable. The present study describes its main geographical and chronological features and presents an up-to-date view of the principal risk factors associated with that disease. Mortality from pancreatic cancer is characterized by its increase with age, its predominance among males and its preferential ethnic and geographical distribution. The most striking point, however, is the increase of incidence noted since 1950, with an as yet unexplained tendency to stabilization. Among the various risk factors suspected of being associated with pancreatic cancer, only tobacco smoking seems to be well established. The methodological problems encountered in analytical studies explain that the role of nutritional, occupational and associated pathological factors remains hypothetical in the present state of our knowledge.
鉴于胰腺癌预后较差，有必要增进我们对其流行病学的了解。本研究描述了胰腺癌主要的地理和时间特征，并呈现了与该疾病相关的主要风险因素的最新观点。胰腺癌死亡率的特点是随年龄增长而上升，男性占主导，且在种族和地域上有特定的分布。然而，最显著的一点是自1950年以来发病率持续上升，且目前有尚未得到解释的稳定趋势。在怀疑与胰腺癌相关的各种风险因素中，只有吸烟似乎是确定的。分析研究中遇到的方法学问题说明，在我们目前的认知水平下，营养、职业和相关病理因素的作用仍属假设。
