Drouillard Antoine, Manfredi Sylvain, Lepage Côme, Bouvier Anne-Marie
Registre Bourguignon des cancers digestifs, Inserm U866, université de Bourgogne, CHU de Dijon, université de Bourgogne, registre Bourguignon des cancers digestifs, Inserm U866, 21000 Dijon, France; Centre hospitalo-universitaire Dijon-Bourgogne, service d'hépato-gastroentérologie et d'oncologie digestive, 21000 Dijon, France.
Registre Bourguignon des cancers digestifs, Inserm U866, université de Bourgogne, CHU de Dijon, université de Bourgogne, registre Bourguignon des cancers digestifs, Inserm U866, 21000 Dijon, France; Centre hospitalo-universitaire Dijon-Bourgogne, service d'hépato-gastroentérologie et d'oncologie digestive, 21000 Dijon, France.
Bull Cancer. 2018 Jan;105(1):63-69. doi: 10.1016/j.bulcan.2017.11.004. Epub 2017 Dec 19.
Actually, pancreatic cancer is a major challenge in digestive oncology. Its prognosis remains very poor with a five-year net survival less than 10%. Although if pancreatic cancer incidence was low, data from French digestive cancer registries show a dramatic increase in recent years, more marked in women (annual variation of +3.6% between 1982 and 2012) than in men (+2.3%). The currently recognized risk factors like tobacco or obesity cannot explain this evolving epidemiology. Moreover, progress in understanding pancreatic carcinogenesis is still insufficient. Except for familial aggregation, systematic screening couldn't be proposed.
实际上，胰腺癌是消化肿瘤学中的一项重大挑战。其预后仍然非常差，五年净生存率不到10%。尽管胰腺癌发病率较低，但法国消化癌症登记处的数据显示，近年来其发病率急剧上升，女性上升幅度（1982年至2012年间年变化率为+3.6%）比男性（+2.3%）更为明显。目前公认的风险因素如吸烟或肥胖并不能解释这种不断变化的流行病学现象。此外，在理解胰腺癌发生机制方面取得的进展仍然不足。除了家族聚集性外，无法进行系统性筛查。
