Latorre X, Cuturi C, Miro J M, Anegon I, Gatell J M, Gallart T, Bruguera M, Pumarola T, Trilla A, Ginel J
Scand J Infect Dis. 1986;18(1):71-8. doi: 10.3109/00365548609032309.
Lymphocyte subpopulations were studied in 29 symptom-free Spanish prisoners who were active parenteral drug abusers. In 16/29 drug addicts (55%) the helper-inducer/suppressor-cytotoxic ratio (Leu 3a/Leu 2a) was less than 1. None of these 16 patients had lymphopenia and only 2 had a reduction in the number of Leu 3a cells. In drug addicts the number of lymphocytes (p less than 0.01) and the number and percentage of Leu 2a cells (p less than 0.001) were significantly raised. The addicts also had a higher absolute number of T cells when measured by their ability to react with the Leu 4 antibody (p less than 0.01). However, the E-rosette forming cells were significantly reduced. Thus the E-rosette test may lead to an overestimation of "null" cells. Furthermore drug addicts had a higher percentage (p less than 0.001) of Leu 7 positive cells (NK and K cells), but a normal percentage of B and phagocytic cells. Five drug addicts had generalized persistent lymphadenopathies, and 2 had skin anergy. We believe that most of the immunologic abnormalities seen in these apparently healthy drug abusers can be explained by an antigenic overload.
对29名无症状的西班牙静脉注射毒品成瘾者的淋巴细胞亚群进行了研究。在29名吸毒者中，有16名（55%）辅助诱导/抑制细胞毒性比值（Leu 3a/Leu 2a）小于1。这16名患者均无淋巴细胞减少，只有2名患者的Leu 3a细胞数量减少。吸毒者的淋巴细胞数量（p<0.01）以及Leu 2a细胞的数量和百分比（p<0.001）显著升高。当通过与Leu 4抗体反应的能力来测量时，吸毒者的T细胞绝对数量也更高（p<0.01）。然而，E玫瑰花结形成细胞显著减少。因此，E玫瑰花结试验可能会导致对“裸”细胞的高估。此外，吸毒者Leu 7阳性细胞（NK细胞和K细胞）的百分比更高（p<0.001），但B细胞和吞噬细胞的百分比正常。5名吸毒者有全身性持续性淋巴结病，2名有皮肤无反应性。我们认为，这些看似健康的吸毒者中出现的大多数免疫异常情况可以用抗原过载来解释。
