Vaught Meghan E, Rozanski Elizabeth A, deLaforcade Armelle M
Section of Critical Care, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts 01536, USA.
Can J Vet Res. 2018 Jan;82(1):75-79.
The purpose of this study was to determine the impact of a transoral tracheal wash (TOTW) on respiratory mechanics in dogs and to describe the use of a critical care ventilator (CCV) to determine respiratory mechanics. Fourteen client-owned dogs with respiratory diseases were enrolled. Respiratory mechanics, including static compliance (C) and static resistance (R), were determined before and after TOTW. Pre- and post-wash results were compared, with a -value of < 0.05 considered significant. The mean ± standard deviation (SD) value of C pre-TOTW was 1.59 ± 0.94 mL/cmHO/kg while the mean ± SD of C post-TOTW was 1.29 ± 0.71 mL/cmHO/kg ( = 0.045). The median R was not significantly different pre- and post-wash. The transoral tracheal wash altered respiratory mechanics, as observed by a reduction in C, presumably due to airway flooding and collapse. While no long-lasting effects were noted in these clinical patients, this effect should be considered when performing TOTW on dogs with respiratory diseases. Respiratory mechanics testing using a CCV was feasible and may be a useful clinical testing approach.
本研究的目的是确定经口气管冲洗(TOTW)对犬类呼吸力学的影响,并描述使用重症监护呼吸机(CCV)来确定呼吸力学。招募了14只患有呼吸道疾病的宠物犬。在TOTW前后测定呼吸力学,包括静态顺应性(C)和静态阻力(R)。比较冲洗前后的结果,P值<0.05被认为具有显著性。TOTW前C的平均值±标准差(SD)为1.59±0.94 mL/cmH₂O/kg,而TOTW后C的平均值±SD为1.29±0.71 mL/cmH₂O/kg(P = 0.045)。冲洗前后R的中位数无显著差异。经口气管冲洗改变了呼吸力学,表现为C降低,推测是由于气道充盈和塌陷所致。虽然在这些临床患者中未观察到长期影响,但在对患有呼吸道疾病的犬进行TOTW时应考虑这种影响。使用CCV进行呼吸力学测试是可行的,可能是一种有用的临床测试方法。