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头颈部癌症患者在肿瘤治疗前后的口腔健康影响概况:一项观察性分析病例对照研究。

Oral health impact profile of head and neck cancer patients after or before oncologic treatment: an observational analytic case-control study.

机构信息

Department of Prosthodontics and Periodontology/Discipline of Periodontology, Bauru School of Dentistry - University of Sao Paulo, Al. Octavio Pinheiro Brisolla 9-75, Bauru, 17012-901, Brazil.

Department of Surgery, Stomatology, Pathology and Radiology/Discipline of Stomatology, Bauru School of Dentistry - University of São Paulo, Al. Octavio Pinheiro Brisolla 9-75, Bauru, 17012-901, Brazil.

出版信息

Support Care Cancer. 2018 Jul;26(7):2185-2189. doi: 10.1007/s00520-018-4066-8. Epub 2018 Jan 30.

Abstract

PURPOSE

The objective of this study was to investigate the impact of oral health on the quality of life of patients with head and neck cancer (HNC) before and after oncologic treatment.

METHODS

Forty cancer-free individuals (Cf group) and 40 HNC patients (Hnc group) were included in this study. Hnc group was also divided into two subgroups: Hnc 1 (pre-cancer therapy, n = 20) and Hnc 2 (post-cancer therapy, n = 20). Participants were asked to complete a short form of Oral Health Impact Profile (OHIP-14). The results were statistically analyzed with the multivariate analysis of variance with post-hoc Scheffé multiple comparison.

RESULTS

It was observed a moderate impact on the quality of life on HNC patients, with values on Hnc 2 group significantly higher in the functional limitation when compared to the Hnc 1 group (p < 0.05). When compared to the Cf group, the values found on Hnc group were higher on functional limitation (p < 0.01) and at the total score (p < 0.05), whereas Hnc 2 group had significant superior values on functional limitation (p < 0.01), physical pain (p < 0.05), and total score (p < 0.01) CONCLUSION: These results show that there is an oral impairment that depreciates the quality of life of patients with an experience of HNC, principally after treatment, indicating the importance of the inclusion of professionals responsible for dental and oral care with the oncologic team to monitor the oral condition of these patients.

摘要

目的

本研究旨在探讨头颈部癌症(HNC)患者在接受肿瘤治疗前后口腔健康对生活质量的影响。

方法

本研究纳入了 40 名无癌症个体(Cf 组)和 40 名 HNC 患者(Hnc 组)。Hnc 组还分为两个亚组:Hnc1(癌症治疗前,n=20)和 Hnc2(癌症治疗后,n=20)。要求参与者完成口腔健康影响简表(OHIP-14)的简短形式。使用事后 Scheffé 多重比较的多变量方差分析对结果进行了统计分析。

结果

观察到 HNC 患者的生活质量受到中度影响,Hnc2 组的功能障碍评分明显高于 Hnc1 组(p<0.05)。与 Cf 组相比,Hnc 组的功能障碍(p<0.01)和总分(p<0.05)评分较高,而 Hnc2 组在功能障碍(p<0.01)、身体疼痛(p<0.05)和总分(p<0.01)方面的评分显著更高。

结论

这些结果表明,HNC 患者存在口腔功能障碍,降低了他们的生活质量,特别是在治疗后,这表明肿瘤治疗团队中应纳入负责口腔和牙科护理的专业人员,以监测这些患者的口腔状况。

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