Barrios Rocío, Bravo Manuel, Gil-Montoya Jose Antonio, Martínez-Lara Ildefonso, García-Medina Blas, Tsakos Georgios
Research Fellow of the Spanish Ministry of Education, School of Dentistry, University of Granada, c/Llanete del Mercado n 5, 23680, Alcalá la Real, Jaen, Spain.
Preventive and Community Dentistry, School of Dentistry, University of Granada, C/Campus Cartuja s/n, 18071, Granada, Spain.
Health Qual Life Outcomes. 2015 Jan 23;13:9. doi: 10.1186/s12955-014-0201-5.
Health-related quality of life (HRQoL) is gaining importance as a valuable outcome measure in oral cancer area. The aim of this study was to assess the general and oral HRQoL of oral and oropharyngeal cancer patients 6 or more months after treatment and compare them with a population free from this disease.
A cross-sectional study was carried out with patients treated for oral cancer at least 6 months post-treatment and a gender and age group matched control group. HRQoL was measured with the 12-Item Short Form Health Survey (SF-12); oral HRQoL (OHRQoL) was evaluated using the Oral Health Impact Profile (OHIP-14) and the Oral Impacts on Daily Performances (OIDP). Multivariable regression models assessed the association between the outcomes (SF-12, OHIP-14 and OIDP) and the exposure (patients versus controls), adjusting for sex, age, social class, functional tooth units and presence of illness.
For patients (n = 142) and controls (n = 142), 64.1% were males. The mean age was 65.2 (standard deviation (sd): 12.9) years in patients and 67.5 (sd: 13.7) years in controls. Patients had worse SF-12 Physical Component Summary scores than controls even in fully the adjusted model [β-coefficient = -0.11 (95% CI: -5.12-(-0.16)]. The differences in SF-12 Mental Component Summary were not statistically significant. Regarding OHRQoL patients had 11.63 (95% CI: 6.77-20.01) higher odds for the OHIP-14 and 21.26 (95% CI: 11.54-39.13) higher odds for OIDP of being in a worse category of OHRQoL compared to controls in the fully adjusted model.
At least 6 months after treatment, oral cancer patients had worse OHRQoL, worse physical HRQoL and similar psychological HRQoL than the general population.
在口腔癌领域，与健康相关的生活质量（HRQoL）作为一种有价值的结局指标正变得越来越重要。本研究的目的是评估口腔和口咽癌患者治疗6个月或更长时间后的总体和口腔HRQoL，并将其与无此病的人群进行比较。
对治疗后至少6个月的口腔癌患者以及性别和年龄组匹配的对照组进行了一项横断面研究。使用12项简短健康调查问卷（SF-12）测量HRQoL；使用口腔健康影响程度量表（OHIP-14）和口腔对日常表现的影响（OIDP）评估口腔HRQoL（OHRQoL）。多变量回归模型评估了结局（SF-12、OHIP-14和OIDP）与暴露因素（患者与对照组）之间的关联，并对性别、年龄、社会阶层、功能性牙单位和疾病存在情况进行了校正。
患者（n = 142）和对照组（n = 142）中，64.1%为男性。患者的平均年龄为65.2岁（标准差（sd）：12.9），对照组为67.5岁（sd：13.7）。即使在完全校正模型中，患者的SF-12身体成分总结得分也比对照组差[β系数 = -0.11（95%置信区间：-5.12 -（-0.16）]。SF-12心理成分总结得分的差异无统计学意义。关于OHRQoL，在完全校正模型中，与对照组相比，患者OHIP-14处于较差OHRQoL类别的几率高11.63（95%置信区间：6.77 - 20.01），OIDP处于较差OHRQoL类别的几率高21.26（95%置信区间：11.54 - 39.13）。
治疗后至少6个月，口腔癌患者的OHRQoL较差，身体HRQoL较差，心理HRQoL与一般人群相似。
