Fyman P N, Hartung J, Casthely P A, Abrams L M, Schneider A, Weinberg S
Acta Anaesthesiol Scand. 1986 Jan;30(1):70-1. doi: 10.1111/j.1399-6576.1986.tb02370.x.
Anesthesia was induced in 42 adults with thiopentone 3-7 mg/kg i.v. and maintained with isoflurane at a constant inspired concentration of 1-2%. After 30 min of hemodynamic stabilization with continuous muscle relaxation and an absence of surgical stimulation, each patient was randomly assigned to one of four metocurine dosage groups: I - control (n = 11); II - 0.2 mg/kg (n = 10); III - 0.3 mg/kg (n = 10); and IV - 0.4 mg/kg (n = 11). There were no significant hemodynamic changes in Groups I or II. In Groups III and IV mean arterial pressure (MAP) decreased 32% and 26% respectively, and systemic vascular resistance (SVR) decreased 42% and 36%, respectively (P less than 0.01). In Group IV, an increase of 24% in cardiac output was also significant (P less than 0.05). These results, especially in Group IV patients, stand in marked contrast to the lack of hemodynamic effects produced by metocurine during balanced anesthesia.
42名成年人静脉注射3 - 7mg/kg硫喷妥钠诱导麻醉，并用异氟烷维持麻醉，吸入浓度恒定在1 - 2%。在持续肌肉松弛且无手术刺激的情况下进行30分钟血流动力学稳定后，每位患者被随机分配到四个美托库铵剂量组之一：I组 - 对照组（n = 11）；II组 - 0.2mg/kg（n = 10）；III组 - 0.3mg/kg（n = 10）；IV组 - 0.4mg/kg（n = 11）。I组和II组未出现明显的血流动力学变化。III组和IV组的平均动脉压（MAP）分别下降了32%和26%，全身血管阻力（SVR）分别下降了42%和36%（P < 0.01）。IV组心输出量增加24%也具有显著性（P < 0.05）。这些结果，尤其是IV组患者的结果，与平衡麻醉期间美托库铵缺乏血流动力学效应形成了显著对比。
