Institute of Pharmaceutical Research, GLA University, NH-2, Mathura-Delhi Road, Mathura (U.P.) - 281 406, India.
Pharmaceutics Research Projects Laboratory, Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Central University, Sagar (M.P.) - 470 003, India.
Curr Drug Targets. 2018;19(13):1498-1518. doi: 10.2174/1389450119666180131105822.
Nanotechnology deals with the manufacturing of materials at the atomic and molecular scale. According to the National Nanotechnology Initiative, nanotechnology denotes those structures which are nearly in 1-100 nm size regime in at least one dimension.
Nanotechnology in drug delivery has been evidenced into nanocarriers that possess distinct properties both in vitro and in vivo, which may be used in targeting drugs to various diseases especially tumors. In the last few years, there has been a keen concern in the formulation of various new drug delivery systems employing nanotechnology. Different nanodevices or nanocarriers like liposomes, dendrimers, polymersomes, transfersomes, and nanoparticles etc. have been employed for the targeted drug delivery.
This review summarizes the advances in nanocarriers in terms of their methods of preparation and potential applications especially in tumors.
纳米技术涉及在原子和分子尺度上制造材料。根据美国国家纳米技术倡议，纳米技术表示在至少一个维度上尺寸接近 1-100nm 的结构。
药物输送中的纳米技术已经证明了纳米载体具有独特的性质，无论是在体外还是体内，都可以用于将药物靶向到各种疾病，特别是肿瘤。在过去的几年中，人们对使用纳米技术的各种新型药物输送系统的配方产生了浓厚的兴趣。不同的纳米器件或纳米载体，如脂质体、树枝状聚合物、聚合物囊泡、转胞囊和纳米颗粒等，已被用于靶向药物输送。
本文综述了纳米载体在制备方法和潜在应用方面的进展，特别是在肿瘤方面的应用。
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