Farokhzad Omid C, Langer Robert
Laboratory of Nanomedicine and Biomaterials and Department of Anesthesiology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
ACS Nano. 2009 Jan 27;3(1):16-20. doi: 10.1021/nn900002m.
Nanotechnology is the engineering and manufacturing of materials at the atomic and molecular scale. In its strictest definition from the National Nanotechnology Initiative, nanotechnology refers to structures roughly in the 1-100 nm size regime in at least one dimension. Despite this size restriction, nanotechnology commonly refers to structures that are up to several hundred nanometers in size and that are developed by top-down or bottom-up engineering of individual components. Herein, we focus on the application of nanotechnology to drug delivery and highlight several areas of opportunity where current and emerging nanotechnologies could enable entirely novel classes of therapeutics.
纳米技术是在原子和分子尺度上对材料进行工程设计和制造。根据美国国家纳米技术计划最严格的定义，纳米技术是指至少在一个维度上尺寸大致在1至100纳米范围内的结构。尽管有这个尺寸限制，但纳米技术通常指的是尺寸达数百纳米且通过单个组件的自上而下或自下而上工程开发的结构。在此，我们重点关注纳米技术在药物递送方面的应用，并突出当前和新兴纳米技术能够催生全新治疗方法的几个机遇领域。
