Gruffat Henri, Manet Evelyne
CIRI, Centre international de recherche en infectiologie, université de Lyon, 69000 Lyon, France - Inserm U1111, Lyon, France - CNRS UMR5308, Lyon, France - École normale supérieure de Lyon, Lyon, France.
Med Sci (Paris). 2018 Jan;34(1):79-82. doi: 10.1051/medsci/20183401017. Epub 2018 Jan 31.
Kaposi's sarcoma human herpesvirus (KSHV) is the etiologic agent of primary effusion lymphoma (PEL) in which Epstein-Barr virus (EBV) is also very often present. By using a humanized mouse model, Pr. Münz's team has been able to demonstrate that EBV/KSHV co-infection increases KSHV persistence and cell transformation through the stimulation of EBV replication. This is the first model of PEL in small animals, opening up exciting prospects for future studies on this unique lymphoma.
卡波西肉瘤人类疱疹病毒（KSHV）是原发性渗出性淋巴瘤（PEL）的病原体，而爱泼斯坦-巴尔病毒（EBV）在这种淋巴瘤中也常常存在。通过使用人源化小鼠模型，明茨教授的团队已经能够证明，EBV/KSHV共同感染通过刺激EBV复制增加了KSHV的持续性和细胞转化。这是第一个小型动物中的PEL模型，为今后对这种独特淋巴瘤的研究开辟了令人兴奋的前景。
