疱疹病毒联手，麻烦加倍。
Double the Trouble When Herpesviruses Join Hands.
作者信息
Choi Un Yung, Park Angela, Jung Jae U
机构信息
Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
出版信息
Cell Host Microbe. 2017 Jul 12;22(1):5-7. doi: 10.1016/j.chom.2017.06.016.
Abstract
KSHV is the etiologic agent of PEL-an aggressive lymphoma. Interestingly, EBV concurrently exists in nearly 70% of PEL cases. In this issue of Cell Host & Microbe, McHugh et al. (2017) develop humanized mouse models for EBV/KSHV co-infection and identify their complementary effect on in vivo tumor formation.
摘要
卡波西肉瘤相关疱疹病毒（KSHV）是原发性渗出性淋巴瘤（PEL，一种侵袭性淋巴瘤）的病原体。有趣的是，在近70%的PEL病例中，EB病毒（EBV）同时存在。在本期的《细胞宿主与微生物》杂志中，麦克休等人（2017年）建立了EBV/KSHV共感染的人源化小鼠模型，并确定了它们在体内肿瘤形成中的互补作用。
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