甲状腺切除术对自发性高血压大鼠的降压作用：心脏功能的相关变化

Antihypertensive effect of thyroidectomy in SHR: associated changes in heart performance.

作者信息

Rodgers R L, McNeill J H

出版信息

Am J Physiol. 1986 Apr;250(4 Pt 2):H600-5. doi: 10.1152/ajpheart.1986.250.4.H600.

DOI:10.1152/ajpheart.1986.250.4.H600

Abstract

Effects of thyroidectomy (TX; 10 wk) on the performance of perfused hearts from spontaneously hypertensive rats (SHR) were compared with effects on hearts from normotensive Wistar-Kyoto (WKY) controls. TX prevented the development of hypertension in SHR and moderately reduced arterial pressure of WKY, confirming previous observations. TX also reduced heart-to-body-weight ratio (relative left ventricular hypertrophy) but not left-to-right ventricular weight ratio (absolute hypertrophy) of SHR. The performances of euthyroid SHR and WKY hearts were similar to each other. TX reduced maximum left ventricular pulse pressure to the same extent in both strains and had no effect on hydraulic work, O2 consumption, or efficiency of contraction in either strain. However, TX reduced maximum left ventricular +dP/dt of SHR but not of WKY hearts. The results show that hypothyroidism selectively depresses the contractility (LV +dP/dt) of SHR hearts but otherwise has similar effects on the performance of hypertensive and normotensive rat hearts.

摘要

将自发性高血压大鼠（SHR）的甲状腺切除（TX；10周）对灌注心脏功能的影响与对正常血压的Wistar-Kyoto（WKY）对照大鼠心脏的影响进行了比较。TX可预防SHR高血压的发展，并适度降低WKY的动脉血压，证实了先前的观察结果。TX还降低了SHR的心脏与体重比（相对左心室肥大），但未降低其左心室与右心室重量比（绝对肥大）。甲状腺功能正常的SHR和WKY心脏的功能彼此相似。TX在两种品系中均将最大左心室脉压降低到相同程度，并且对两种品系的水力功、耗氧量或收缩效率均无影响。然而，TX降低了SHR心脏的最大左心室 +dP/dt，但对WKY心脏没有影响。结果表明，甲状腺功能减退选择性地抑制了SHR心脏的收缩力（左心室 +dP/dt），但在其他方面对高血压和正常血压大鼠心脏的功能有相似影响。