Kurihara Kensuke, Ueda Motoki, Hara Isao, Ozeki Eiichi, Togashi Kaori, Kimura Shunsaku
Clinical Division of Diagnostic Radiology, Kyoto University Hospital 54 Shogoin Kawara-cho, Sakyo-ku, Kyoto 606-8507, Japan.
Technology Research Laboratory, Shimadzu Corporation, Kyoto 619-0237, Japan.
Nanomaterials (Basel). 2018 Jan 31;8(2):79. doi: 10.3390/nano8020079.
Polymeric micelle of the A₃B-type lactosome comprising (poly(sarcosine))₃--poly(l-lactic acid) was labeled with In. The In-labeled A₃B-type lactosome was administered to the model mice bearing meningeal dissemination and bone metastasis at mandible. With single-photon emission computed tomography (SPECT) imaging, the meningeal dissemination was identified successfully by In-labeled A₃B-type lactosome, which was superior to TlCl in regard of the imaging contrast. The In-labeled A₃B-type lactosome was also potential in imaging selectively of bone metastasis at mandible, whilst a nonspecific imaging of the whole bone was obtained by the SPECT imaging using Tc-HMDP. The polymeric micelle of the A₃B-type lactosome was therefore found to be effective as a vehicle of In to be targeted to meningeal dissemination and bone metastasis.
由（聚肌氨酸）₃-聚（L-乳酸）组成的A₃B型脂质体聚合物胶束用铟进行了标记。将铟标记的A₃B型脂质体给予患有脑膜播散和下颌骨骨转移的模型小鼠。通过单光子发射计算机断层扫描（SPECT）成像，铟标记的A₃B型脂质体成功识别出脑膜播散，在成像对比度方面优于氯化铊。铟标记的A₃B型脂质体在选择性成像下颌骨骨转移方面也具有潜力，而使用锝-亚甲基二膦酸盐（Tc-HMDP）的SPECT成像获得的是整个骨骼的非特异性成像。因此，发现A₃B型脂质体聚合物胶束作为铟的载体靶向脑膜播散和骨转移是有效的。
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