Crabb D W
Alcohol Clin Exp Res. 1986 Jan-Feb;10(1):77-80. doi: 10.1111/j.1530-0277.1986.tb05619.x.
The effect of experimental diabetes on the activity of liver alcohol dehydrogenase was studied in males and females of two strains of rats. Alloxan diabetes of 8 weeks duration increased the activity of alcohol dehydrogenase in Sprague-Dawley males by about 50%. This effect was also observed in rats rendered diabetic with streptozotocin. However, there was no increase in the enzyme activity in female Sprague-Dawley rats. The magnitude of the increase was much less in diabetic Wistar-Kyoto males than in Sprague-Dawley males. Plasma concentrations of thyroxine were lower in diabetic animals than in controls, but this effect of diabetes did not correlate with changes in alcohol dehydrogenase activity. There was no reduction in plasma testosterone concentration in diabetic Sprague-Dawley rats. Growth hormone levels were not increased in the diabetic rats. The mechanism of the increase in liver alcohol dehydrogenase activity in diabetic male Sprague-Dawley rats is unknown.
研究了实验性糖尿病对两种品系大鼠雄性和雌性肝脏乙醇脱氢酶活性的影响。持续8周的四氧嘧啶糖尿病使斯普拉格-道利雄性大鼠的乙醇脱氢酶活性提高了约50%。用链脲佐菌素使大鼠患糖尿病时也观察到了这种效应。然而，雌性斯普拉格-道利大鼠的酶活性没有增加。糖尿病的Wistar-Kyoto雄性大鼠酶活性增加的幅度远小于斯普拉格-道利雄性大鼠。糖尿病动物的血浆甲状腺素浓度低于对照组，但糖尿病的这种效应与乙醇脱氢酶活性的变化无关。糖尿病的斯普拉格-道利大鼠血浆睾酮浓度没有降低。糖尿病大鼠的生长激素水平没有升高。糖尿病雄性斯普拉格-道利大鼠肝脏乙醇脱氢酶活性增加的机制尚不清楚。
