Maesen F P, Smeets J J, Bernsen R, Cornelissen P J
Allergy. 1986 Jan;41(1):37-42. doi: 10.1111/j.1398-9995.1986.tb00272.x.
The bronchospasmolytic effects of 40 micrograms ipratropium bromide (Atrovent) given either as an aerosol (2 puffs of 20 micrograms) or as a powder inhalation were compared in a double-blind cross-over study. Following a randomisation list the drug was given on 2 successive days to 20 patients with stable bronchospasm in whom it had previously been shown that the bronchial obstruction was reversible after administration of 40 micrograms ipratropium bromide as an aerosol (with an increase over the baseline value of the FEV1 of at least 15% 1 h after drug administration). The effects of the two presentations of ipratropium bromide were followed by respiratory function tests from 15 min to 6 h after administration of the drug. With both formulations excellent bronchospasmolytic effects were noted in each of the parameters measured. The peak of the effects was noted approximately 1 h after the inhalations. Six hours later there was still a significant improvement in comparison with the baseline values. There was no significant difference between the results with the two different formulations. Inhalation powder of ipratropium bromide was well tolerated and there were no complaints of irritation or coughing. It would appear, therefore, to be a valuable alternative to the pressure aerosol.
在一项双盲交叉研究中，比较了40微克异丙托溴铵（爱全乐）以气雾剂形式（2喷，每喷20微克）或粉末吸入形式给药后的支气管解痉作用。按照随机列表，连续2天将药物给予20例稳定期支气管痉挛患者，此前已证明这些患者在以气雾剂形式给予40微克异丙托溴铵后支气管阻塞是可逆的（给药后1小时FEV1较基线值增加至少15%）。在给予药物后15分钟至6小时进行呼吸功能测试，观察两种剂型异丙托溴铵的效果。两种剂型在每个测量参数中均观察到良好的支气管解痉作用。吸入后约1小时达到效果峰值。6小时后与基线值相比仍有显著改善。两种不同剂型的结果之间无显著差异。异丙托溴铵吸入粉耐受性良好，无刺激或咳嗽主诉。因此，它似乎是压力气雾剂的一个有价值的替代品。
