Woodcock A, Humberstone A, Sutton B, Law A, Lytton S, Newey M, Pike S
Pharmatherapeutica. 1984;4(1):32-5.
A randomized crossover study was carried out in 12 patients with reversible airflow obstruction to investigate the bronchodilator effects of a single metered dose of fenoterol hydrobromide (200 micrograms) plus ipratropium bromide (80 micrograms) delivered by the standard aerosol inhaler or by the inhaler with an extension tube spacer. The results of lung function tests showed that there were significant increases from baseline values in FEV1, FVC and PEFR by 15 minutes using both drug delivery methods, and the improvement in PEFR was maintained for at least 8 hours in 11 of the 12 patients. Although no significant differences in the results was demonstrated between the two methods, which were used correctly by all the participants, it is suggested that the spacer device method would be particularly useful for patients who have difficulty in co-ordinating drug delivery with inhalation.
对12例可逆性气流阻塞患者进行了一项随机交叉研究，以调查通过标准气雾剂吸入器或带有延长管储雾罐的吸入器给予单剂量定量的氢溴酸非诺特罗（200微克）加异丙托溴铵（80微克）的支气管扩张作用。肺功能测试结果显示，使用两种给药方法，15分钟时FEV1、FVC和PEFR均较基线值显著增加，12例患者中有11例的PEFR改善至少维持了8小时。尽管所有参与者正确使用这两种方法时结果无显著差异，但建议储雾罐装置方法对难以将药物输送与吸入协调配合的患者特别有用。
