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肌毒素a与骨骼肌肌浆网Ca2+-ATP酶的相互作用。

Interaction of myotoxin a with the Ca2+-ATPase of skeletal muscle sarcoplasmic reticulum.

作者信息

Volpe P, Damiani E, Maurer A, Tu A T

出版信息

Arch Biochem Biophys. 1986 Apr;246(1):90-7. doi: 10.1016/0003-9861(86)90452-2.

DOI:10.1016/0003-9861(86)90452-2
PMID:2938545
Abstract

Myotoxin a is a muscle-damaging toxin isolated from the venom of Crotalus viridis viridis. Its interaction with the Ca2+-ATPase of sarcoplasmic reticulum (SR) vesicles purified from rabbit skeletal muscle was investigated. Myotoxin a inhibited Ca2+ loading and stimulated Ca2+-dependent ATPase without affecting unidirectional Ca2+ efflux. Its action was dose, time, and temperature dependent. Myotoxin a partially blocked the binding of specific anti-(rabbit SR Ca2+-ATPase) antibodies. It is concluded that myotoxin a attaches to the SR Ca2+-ATPase and uncouples Ca2+ uptake from Ca2+-dependent ATP hydrolysis. Myotoxin a also prevented the formation of decavanadate-induced two-dimensional crystalline arrays of the SR Ca2+-ATPase.

摘要

肌毒素a是一种从绿曼巴蛇毒液中分离出的肌肉损伤毒素。研究了它与从兔骨骼肌中纯化的肌浆网（SR）囊泡的Ca2+-ATP酶的相互作用。肌毒素a抑制Ca2+的装载并刺激Ca2+依赖性ATP酶，而不影响单向Ca2+外流。其作用具有剂量、时间和温度依赖性。肌毒素a部分阻断了特异性抗（兔SR Ca2+-ATP酶）抗体的结合。得出的结论是，肌毒素a附着于SR Ca2+-ATP酶，并使Ca2+摄取与Ca2+依赖性ATP水解解偶联。肌毒素a还阻止了十钒酸盐诱导的SR Ca2+-ATP酶二维晶体阵列的形成。

相似文献

1
Interaction of myotoxin a with the Ca2+-ATPase of skeletal muscle sarcoplasmic reticulum.肌毒素a与骨骼肌肌浆网Ca2+-ATP酶的相互作用。
Arch Biochem Biophys. 1986 Apr;246(1):90-7. doi: 10.1016/0003-9861(86)90452-2.
2
Crystallization of the Ca2+-ATPase of skeletal muscle sarcoplasmic reticulum. Inhibition by myotoxin a.骨骼肌肌浆网Ca2+-ATP酶的结晶。被肌毒素a抑制。
FEBS Lett. 1987 Nov 16;224(1):89-96. doi: 10.1016/0014-5793(87)80428-3.
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Arch Biochem Biophys. 1988 Oct;266(1):171-80. doi: 10.1016/0003-9861(88)90247-0.
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Binding of myotoxin a to sarcoplasmic reticulum Ca(2+)-ATPase: a structural study.肌毒素a与肌浆网Ca(2+)-ATP酶的结合：一项结构研究。
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Competition between decavanadate and fluorescein isothiocyanate on the Ca2+-ATPase of sarcoplasmic reticulum.十钒酸盐与异硫氰酸荧光素对肌浆网Ca2+-ATP酶的竞争作用
Eur J Biochem. 1985 Aug 1;150(3):455-60. doi: 10.1111/j.1432-1033.1985.tb09043.x.
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Structure-function relationship of myotoxin a using peptide fragments.使用肽片段研究肌毒素a的结构-功能关系。
Arch Biochem Biophys. 1992 Nov 1;298(2):325-31. doi: 10.1016/0003-9861(92)90418-v.
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The binding of vanadium (V) oligoanions to sarcoplasmic reticulum.钒（V）低聚阴离子与肌浆网的结合。
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Myotoxin a reduces the threshold for calcium-induced calcium release in skeletal muscle.肌毒素a降低了骨骼肌中钙诱导的钙释放阈值。
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Comparison of the effects of fluoride on the calcium pumps of cardiac and fast skeletal muscle sarcoplasmic reticulum: evidence for tissue-specific qualitative difference in calcium-induced pump conformation.氟化物对心肌和快肌骨骼肌肌浆网钙泵作用的比较：钙诱导泵构象存在组织特异性质的差异的证据
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Ca2+ release induced by myotoxin alpha, a radio-labellable probe having novel Ca2+ release properties in sarcoplasmic reticulum.肌毒素α诱导的钙离子释放，肌毒素α是一种在肌浆网中具有新型钙离子释放特性的放射性可标记探针。
Br J Pharmacol. 1994 Sep;113(1):233-9. doi: 10.1111/j.1476-5381.1994.tb16199.x.

引用本文的文献

1
CIDNP study of the aromatic side chain interactions in myotoxin alpha.肌毒素α中芳香族侧链相互作用的化学诱导动态核极化研究
J Protein Chem. 1994 Apr;13(3):333-7. doi: 10.1007/BF01901566.
2
Ca2+ release induced by myotoxin alpha, a radio-labellable probe having novel Ca2+ release properties in sarcoplasmic reticulum.肌毒素α诱导的钙离子释放，肌毒素α是一种在肌浆网中具有新型钙离子释放特性的放射性可标记探针。
Br J Pharmacol. 1994 Sep;113(1):233-9. doi: 10.1111/j.1476-5381.1994.tb16199.x.
3
Mechanism of inhibition of Ca(2+)-ATPase by myotoxin a.肌毒素a对Ca(2+)-ATP酶的抑制机制。
Biochem J. 1995 Apr 15;307 ( Pt 2)(Pt 2):571-9. doi: 10.1042/bj3070571.
4
Pharmacology of calcium release from sarcoplasmic reticulum.肌浆网钙释放的药理学
J Bioenerg Biomembr. 1989 Apr;21(2):295-320. doi: 10.1007/BF00812074.