罕见肿瘤中的小分子：miRNAs 在 GIST 中的新作用。
Small Molecules in Rare Tumors: Emerging Role of MicroRNAs in GIST.
机构信息
Institute for Digestive Research, Academy of Medicine, Lithuanian University of Health Sciences, Eiveniu str. 2, LT-50009 Kaunas, Lithuania.
Department of Gastroenterology, Academy of Medicine, Lithuanian University of Health Sciences, Eiveniu str. 2, LT-50009 Kaunas, Lithuania.
出版信息
Int J Mol Sci. 2018 Jan 30;19(2):397. doi: 10.3390/ijms19020397.
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of gastrointestinal tract. GISTs have very different clinical phenotypes and underlying molecular characteristics that are not yet completely understood. microRNAs (miRNAs) have been shown to participate in carcinogenesis pathways through post-transcriptional regulation of gene expression in different tumors. Over the last years emerging evidence has highlighted the role of miRNAs in GISTs. This review provides an overview of original research papers that analyze miRNA deregulation patterns, functional role, diagnostic, therapeutic and prognostic implications in GIST as well as provides directions for further research in the field.
胃肠道间质瘤（GISTs）是胃肠道最常见的间叶性肿瘤。GISTs 具有非常不同的临床表型和潜在的分子特征，目前尚未完全了解。microRNAs（miRNAs）已被证明通过不同肿瘤中转录后基因表达的调控参与癌发生途径。近年来，新出现的证据强调了 miRNAs 在 GISTs 中的作用。这篇综述提供了对分析 miRNA 失调模式、功能作用、诊断、治疗和预后意义的原始研究论文的概述，以及该领域进一步研究的方向。
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