[生物活性天然产物的立体控制全合成]
[Stereocontrolled Total Synthesis of Biologically Active Natural Products].
作者信息
Hatakeyama Susumi
机构信息
Graduate School of Biomedical Sciences, Nagasaki University.
出版信息
Yakugaku Zasshi. 2018;138(2):191-209. doi: 10.1248/yakushi.17-00187.
PMID:29386433
Abstract
This review article describes the total syntheses of englerin A, ophiodilactones A and B, marinomycin A, N-methylwelwitindolinone C isothiocyanate, tirandamycins A-D, and tirandalydigin, which possess intriguing biological activities and challenging structures with characteristic ring systems. The focus is on the synthetic methodologies that lead to the highly stereocontrolled assembly of these natural products.
摘要
这篇综述文章描述了恩格勒菌素A、蛇形双内酯A和B、马立诺霉素A、N-甲基维维菌素C异硫氰酸酯、替兰霉素A-D以及替兰地吉因的全合成，这些化合物具有引人关注的生物活性和带有特征性环系的具有挑战性的结构。重点在于导致这些天然产物高度立体控制组装的合成方法。
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