Mori Yuki, Kinoshita Fumiya, Takada Hiroki
Department of Human and Artificial Intelligent Systems, Graduate School of Engineering, University of Fukui.
Department of Information Engineering, Graduate School of Information Science, Nagoya University.
Nihon Eiseigaku Zasshi. 2018;73(1):34-38. doi: 10.1265/jjh.73.34.
Contingent negative variation (CNV) is an event-related potential proportional to vigilance degree. A CNV graph shows an inverted U-shape, and this bioreaction disappears after falling below a threshold of vigilance degree. Previous studies have shown that the event-related potential gained with time decreases with sleep deprivation, and a decrease in the vigilance degree has been confirmed using Flicker values (FV) and the Stanford Sleepiness Scale (SSS) score. The minimum integrated value was recorded 24 h after the onset of sleep deprivation. In a present study, we used 36-h sleep deprivation. The FVs, SSS scores, and stabilograms were obtained every 90 min for 52 h, except for the 12 h of sleep. We herein examine whether the biocontrol system is changed by sleep deprivation.
The time sequences in FV and SSS score showed that the degree of vigilance markedly decreased 22.5 h after the onset of this experiment, which supported CNV disappearance with sleep deprivation. The sway value with subjects' eyes closed was greatest 22.5 h after the onset of this experiment. Furthermore, there were no significant differences between the sway value during the above-mentioned sleep deprivation and that after 12 h of sleep. We considered that the equilibrium function and vigilance after 36-h sleep deprivation did not recover markedly well with sleep of sufficient duration. That is, the biocontrol process in the subconscious still proceeds after awakening.
In this study, we focused on bioprocessing, especially the equilibrium function, during sleep deprivation and investigated the relationship between the equilibrium function and sleep deprivation. We obtained evidence supporting CNV disappearance after sleep deprivation for 36 h. The equilibrium control system without CNV was compared with that with CNV.
关联性负变（CNV）是一种与警觉程度成正比的事件相关电位。CNV图呈倒U形，当警觉程度降至阈值以下时，这种生物反应就会消失。先前的研究表明，随着时间推移获得的事件相关电位会因睡眠剥夺而降低，并且使用闪烁值（FV）和斯坦福嗜睡量表（SSS）评分已证实警觉程度有所下降。在睡眠剥夺开始后24小时记录到最低积分值。在本研究中，我们采用了36小时睡眠剥夺。除了12小时睡眠外，在52小时内每90分钟获取一次FV、SSS评分和稳定图。我们在此研究生物控制系统是否会因睡眠剥夺而改变。
FV和SSS评分的时间序列表明，在本实验开始后22.5小时，警觉程度显著下降，这支持了睡眠剥夺导致CNV消失的观点。在本实验开始后22.5小时，受试者闭眼时的摆动值最大。此外，上述睡眠剥夺期间的摆动值与睡眠12小时后的摆动值之间没有显著差异。我们认为，36小时睡眠剥夺后的平衡功能和警觉性并没有因足够时长的睡眠而明显恢复良好。也就是说，潜意识中的生物控制过程在醒来后仍在继续。
在本研究中，我们关注睡眠剥夺期间的生物过程，尤其是平衡功能，并研究了平衡功能与睡眠剥夺之间的关系。我们获得了支持36小时睡眠剥夺后CNV消失的证据。将没有CNV的平衡控制系统与有CNV的平衡控制系统进行了比较。
