通过选择离子监测测定苯环己哌啶的氨基酸代谢物。

Measurement of the amino acid metabolite of phencyclidine by selected ion monitoring.

作者信息

Syracuse C D, Kuhnert B R, Golden N L, Bagby B S

出版信息

Biomed Environ Mass Spectrom. 1986 Mar;13(3):113-5. doi: 10.1002/bms.1200130303.

DOI:10.1002/bms.1200130303

Abstract

A technique is described for the extraction and quantitation of the pentanoic acid metabolite of phencyclidine by gas chromatography/mass spectrometry. This compound was measured in urine samples from asymptomatic pregnant patients who used phencyclidine (PCP) and their neonates. The technique is sensitive to 25 ng ml-1 urine and standard curves were linear at 25-2000 ng ml-1. Levels in samples from asymptomatic patients were 27-1388 ng ml-1. Results suggest that the pentanoic acid metabolite could be considered as a screening marker for occasional PCP use.

摘要

描述了一种通过气相色谱/质谱法提取和定量苯环利定戊酸代谢物的技术。在使用苯环利定（PCP）的无症状孕妇及其新生儿的尿液样本中测量了该化合物。该技术对尿液中25 ng ml-1敏感，标准曲线在25 - 2000 ng ml-1范围内呈线性。无症状患者样本中的水平为27 - 1388 ng ml-1。结果表明，戊酸代谢物可被视为偶尔使用PCP的筛查标志物。