低氧细胞放射增敏剂Ro 03-8799与SR 2508联合应用的I期研究：单剂量毒性、药代动力学及肿瘤浓度的初步报告 - Suppr | 超能文献

A phase I study of the combined hypoxic cell radiosensitizers, Ro 03-8799 and SR 2508: a preliminary report of single-dose toxicity, pharmacokinetics and tumour concentrations.

作者信息

Newman H F, Bleehen N M, Workman P

出版信息

Br J Radiol. 1986 Apr;59(700):423-5. doi: 10.1259/0007-1285-59-700-423.

DOI:10.1259/0007-1285-59-700-423

Abstract

摘要

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1

A phase I study of the combined hypoxic cell radiosensitizers, Ro 03-8799 and SR 2508: a preliminary report of single-dose toxicity, pharmacokinetics and tumour concentrations.低氧细胞放射增敏剂Ro 03-8799与SR 2508联合应用的I期研究：单剂量毒性、药代动力学及肿瘤浓度的初步报告

Br J Radiol. 1986 Apr;59(700):423-5. doi: 10.1259/0007-1285-59-700-423.

2

A phase I study of the combination of two hypoxic cell radiosensitizers, Ro 03-8799 and SR-2508: toxicity and pharmacokinetics.两种低氧细胞放射增敏剂Ro 03-8799与SR-2508联合应用的I期研究：毒性与药代动力学

Int J Radiat Oncol Biol Phys. 1986 Jul;12(7):1113-6. doi: 10.1016/0360-3016(86)90238-5.

3

Radiosensitization by the combination of etanidazole (SR-2508) and pimonidazole (Ro 03-8799) in human tumor xenografts.依他硝唑（SR - 2508）与匹莫硝唑（Ro 03 - 8799）联合应用对人肿瘤异种移植瘤的放射增敏作用

Int J Radiat Oncol Biol Phys. 1991 Nov;21(6):1535-40. doi: 10.1016/0360-3016(91)90330-7.

4

Gradient high-performance liquid chromatographic method for simultaneous assay of the radiosensitizers etanidazole (SR 2508) and pimonidazole (Ro 03-8799) in biological materials.梯度高效液相色谱法同时测定生物材料中的放射增敏剂依他硝唑（SR 2508）和匹莫硝唑（Ro 03 - 8799）

J Chromatogr. 1987 Sep 4;420(1):223-7. doi: 10.1016/0378-4347(87)80178-0.

5

The clinical testing of Ro 03-8799--pharmacokinetics, toxicology, tissue and tumor concentrations.Ro 03 - 8799的临床试验——药代动力学、毒理学、组织及肿瘤浓度

Int J Radiat Oncol Biol Phys. 1984 Sep;10(9):1759-63. doi: 10.1016/0360-3016(84)90544-3.

6

Initial report of the phase I trial of the hypoxic cell radiosensitizer SR-2508.缺氧细胞放射增敏剂SR - 2508的I期试验初步报告。

Int J Radiat Oncol Biol Phys. 1984 Sep;10(9):1749-53. doi: 10.1016/0360-3016(84)90542-x.

7

A phase I study of the hypoxic cell radiosensitizer Ro-03-8799.乏氧细胞放射增敏剂Ro-03-8799的I期研究。

Int J Radiat Oncol Biol Phys. 1984 Sep;10(9):1755-8. doi: 10.1016/0360-3016(84)90543-1.

8

Pharmacokinetics and toxicology of continuously infused nitroimidazoles.持续输注硝基咪唑类药物的药代动力学与毒理学

Int J Radiat Oncol Biol Phys. 1984 Aug;10(8):1311-4. doi: 10.1016/0360-3016(84)90338-9.

9

The radiosensitizer Ro 03-8799 and the concentrations which may be achieved in human tumours: a preliminary study.放射增敏剂Ro 03 - 8799及其在人类肿瘤中可能达到的浓度：一项初步研究。

Br J Cancer. 1982 Nov;46(5):706-10. doi: 10.1038/bjc.1982.262.

10

Abnormal clinical pharmacokinetics of the developmental radiosensitizers pimonidazole (Ro 03-8799) and etanidazole (SR 2508).放射增敏剂匹莫硝唑（Ro 03-8799）和依他硝唑（SR 2508）的异常临床药代动力学。

Int J Radiat Oncol Biol Phys. 1990 May;18(5):1151-6. doi: 10.1016/0360-3016(90)90452-p.

引用本文的文献

1

Relationship between the melanin content of a human melanoma cell line and its radiosensitivity and uptake of pimonidazole.人黑色素瘤细胞系的黑色素含量与其放射敏感性及匹莫硝唑摄取之间的关系

Cancer Chemother Pharmacol. 1993;31(4):277-82. doi: 10.1007/BF00685671.

2

When can the infusion period be safely ignored in the estimation of pharmacokinetic parameters of drugs in humans?在估算人体药物的药代动力学参数时，何时可以安全地忽略输注期？

Cancer Chemother Pharmacol. 1988;22(2):95-103. doi: 10.1007/BF00257304.

3

Lack of stereoselectivity in the pharmacokinetics and metabolism of the radiosensitizer Ro 03-8799 in man.放射增敏剂Ro 03-8799在人体药代动力学和代谢过程中缺乏立体选择性。

Cancer Chemother Pharmacol. 1991;28(2):118-22. doi: 10.1007/BF00689700.