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1
The radiosensitizer Ro 03-8799 and the concentrations which may be achieved in human tumours: a preliminary study.放射增敏剂Ro 03 - 8799及其在人类肿瘤中可能达到的浓度：一项初步研究。
Br J Cancer. 1982 Nov;46(5):706-10. doi: 10.1038/bjc.1982.262.
2
A phase I study of the hypoxic cell radiosensitizer Ro-03-8799.乏氧细胞放射增敏剂Ro-03-8799的I期研究。
Int J Radiat Oncol Biol Phys. 1984 Sep;10(9):1755-8. doi: 10.1016/0360-3016(84)90543-1.
3
The clinical testing of Ro 03-8799--pharmacokinetics, toxicology, tissue and tumor concentrations.Ro 03 - 8799的临床试验——药代动力学、毒理学、组织及肿瘤浓度
Int J Radiat Oncol Biol Phys. 1984 Sep;10(9):1759-63. doi: 10.1016/0360-3016(84)90544-3.
4
A phase I clinical study of Nimorazole as a hypoxic radiosensitizer.尼莫唑作为乏氧放疗增敏剂的I期临床研究。
Int J Radiat Oncol Biol Phys. 1984 Sep;10(9):1765-8. doi: 10.1016/0360-3016(84)90545-5.
5
Serum concentration measurements in man of the radiosensitizer Ro-07-0582: some preliminary results.放射增敏剂Ro-07-0582在人体中的血清浓度测量：一些初步结果。
Br J Cancer. 1975 Jun;31(6):679-83. doi: 10.1038/bjc.1975.115.
6
Concentrations achieved in human tumors after administration of misonidazole, SR-2508 and Ro 03-8799.给予米索硝唑、SR - 2508和Ro 03 - 8799后在人类肿瘤中达到的浓度。
Int J Radiat Oncol Biol Phys. 1986 Jul;12(7):1109-11. doi: 10.1016/0360-3016(86)90237-3.
7
The concentration of desmethylmisonidazole in human tumours and in cerebrospinal fluid.去甲基米索硝唑在人体肿瘤组织和脑脊液中的浓度。
Br J Cancer. 1981 Mar;43(3):344-9. doi: 10.1038/bjc.1981.54.
8
A phase I study of the combined hypoxic cell radiosensitizers, Ro 03-8799 and SR 2508: a preliminary report of single-dose toxicity, pharmacokinetics and tumour concentrations.低氧细胞放射增敏剂Ro 03-8799与SR 2508联合应用的I期研究：单剂量毒性、药代动力学及肿瘤浓度的初步报告
Br J Radiol. 1986 Apr;59(700):423-5. doi: 10.1259/0007-1285-59-700-423.
9
Pharmacokinetic considerations in testing hypoxic cell radiosensitizers in mouse tumours.在小鼠肿瘤中测试乏氧细胞放射增敏剂时的药代动力学考量
Br J Cancer. 1979 Mar;39(3):310-20. doi: 10.1038/bjc.1979.55.
10
Clinical testing of the radiosensitizer Ro 07-0582: experience with multiple doses.放射增敏剂Ro 07-0582的临床试验：多次给药的经验
Br J Cancer. 1977 May;35(5):567-79. doi: 10.1038/bjc.1977.90.

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Prodrugs of a 1-Hydroxy-2-oxopiperidin-3-yl Phosphonate Enolase Inhibitor for the Treatment of -Deleted Cancers.1-羟基-2-氧代哌啶-3-基膦酸酯烯醇酶抑制剂前药治疗 - 删除癌症。
J Med Chem. 2022 Oct 27;65(20):13813-13832. doi: 10.1021/acs.jmedchem.2c01039. Epub 2022 Oct 17.
2
Radiation sensitization and chemopotentiation: RSU 1069, a compound more efficient than misonidazole in vitro and in vivo.辐射增敏与化学增效作用：RSU 1069，一种在体外和体内比灭滴灵更有效的化合物。
Br J Cancer. 1984 May;49(5):571-7. doi: 10.1038/bjc.1984.91.
3
The pharmacokinetics of a new radiosensitiser, Ro 03-8799 in humans.新型放射增敏剂Ro 03-8799在人体中的药代动力学。
Eur J Clin Pharmacol. 1984;27(4):483-9. doi: 10.1007/BF00549599.
4
Autoradiographic distribution of [14C]-labelled pimonidazole in rhabdomyosarcoma-bearing rats and pigmented mice.[14C]标记的匹莫硝唑在荷横纹肌肉瘤大鼠和有色小鼠体内的放射自显影分布
Cancer Chemother Pharmacol. 1988;22(4):308-15. doi: 10.1007/BF00254237.
5
High uptake of RSU 1069 and its analogues melanotic melanomas.RSU 1069及其类似物在黑色素瘤中摄取率高。
Cancer Chemother Pharmacol. 1989;24(1):28-32. doi: 10.1007/BF00254101.

本文引用的文献

1
The concentration of desmethylmisonidazole in human tumours and in cerebrospinal fluid.去甲基米索硝唑在人体肿瘤组织和脑脊液中的浓度。
Br J Cancer. 1981 Mar;43(3):344-9. doi: 10.1038/bjc.1981.54.
2
A serial study of the concentration of misonidazole in human tumors correlated with histologic structure.一项关于人肿瘤中米索硝唑浓度与组织结构相关性的系列研究。
Int J Radiat Oncol Biol Phys. 1981 Feb;7(2):197-203. doi: 10.1016/0360-3016(81)90437-5.
3
In vivo assessment of basic 2-nitroimidazole radiosensitizers.2-硝基咪唑类基础放射增敏剂的体内评估
Br J Cancer. 1982 Jul;46(1):127-37. doi: 10.1038/bjc.1982.174.
4
Neurotoxicity with desmethylmisonidazole.去甲基米索硝唑的神经毒性。
Br J Radiol. 1981 Feb;54(638):156-7. doi: 10.1259/0007-1285-54-638-156.

放射增敏剂Ro 03 - 8799及其在人类肿瘤中可能达到的浓度：一项初步研究。

The radiosensitizer Ro 03-8799 and the concentrations which may be achieved in human tumours: a preliminary study.

作者信息

Saunders M I, Dische S, Fermont D, Bishop A, Lenox-Smith I, Allen J G, Malcolm S L

出版信息

Br J Cancer. 1982 Nov;46(5):706-10. doi: 10.1038/bjc.1982.262.

DOI:10.1038/bjc.1982.262
PMID:7171452
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2011152/
Abstract

A new hypoxic cell radiosensitizer, Ro 03-8799, has been administered i.v. to 2 normal and 6 patient volunteers. Generally in non-necrotic tumours the concentrations obtained were 3 times greater than in plasma sampled at the same time. These observations added to the reports concerning toxicology in monkeys and rats and radiosensitizing efficiency in the laboratory, suggest that Ro 03-8799 may prove to be much more effective sensitizer than misonidazole in man.

摘要

一种新型低氧细胞放射增敏剂Ro 03 - 8799已通过静脉注射给予2名正常志愿者和6名患者志愿者。一般来说，在非坏死性肿瘤中获得的浓度比同时采集的血浆中的浓度高3倍。这些观察结果，再加上有关猴子和大鼠毒理学以及实验室放射增敏效率的报告，表明Ro 03 - 8799在人体中可能被证明是比米索硝唑更有效的增敏剂。