Guerra-Gomes Sónia, Sousa Nuno, Pinto Luísa, Oliveira João F
Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
ICVS/3B's - PT Government Associate Laboratory, Braga, Portugal.
Front Cell Neurosci. 2018 Jan 17;11:427. doi: 10.3389/fncel.2017.00427. eCollection 2017.
Astrocytes are fundamental players in the regulation of synaptic transmission and plasticity. They display unique morphological and phenotypical features that allow to monitor and to dynamically respond to changes. One of the hallmarks of the astrocytic response is the generation of calcium elevations, which further affect downstream cellular processes. Technical advances in the field have allowed to spatially and to temporally quantify and qualify these elevations. However, the impact on brain function remains poorly understood. In this review, we discuss evidences of the functional impact of heterogeneous astrocytic calcium events in several brain regions, and their consequences in synapses, circuits, and behavior.
星形胶质细胞是调节突触传递和可塑性的重要参与者。它们表现出独特的形态和表型特征，使其能够监测并动态响应变化。星形胶质细胞反应的一个标志是钙离子浓度升高，这会进一步影响下游细胞过程。该领域的技术进步使得能够在空间和时间上对这些浓度升高进行量化和定性。然而，其对脑功能的影响仍知之甚少。在这篇综述中，我们讨论了不同星形胶质细胞钙事件在几个脑区的功能影响及其对突触、神经回路和行为的影响的证据。
