衰老和老年衰弱中应激与炎症分子机制的见解
Insights into the molecular mechanisms of stress and inflammation in ageing and frailty of the elderly.
作者信息
Vlachakis Dimitrios, Zacharaki Evangelia I, Tsiamaki Eirini, Koulouri Maria, Raftopoulou Sofia, Papageorgiou Louis, Chrousos George P, Ellul John, Megalooikonomou Vasileios
机构信息
Computer Engineering and Informatics Department, School of Engineering, University of Patras, Patras 26500, Greece.
Division of Endocrinology and Metabolism, Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
出版信息
J Mol Biochem. 2017;6:41-44. Epub 2017 Dec 10.
Frailty is a natural state of physical, cognitive and mental decline that is expected in the elderly. The role of inflammation in the pathogenesis of frailty has been hypothesized, and so far many studies have been performed in order to understand the mechanism of action underlying this association. Recent studies support this hypothesis and show a clear association between inflammation, frailty, and age-related disease. Chronic inflammation is key pathophysiologic process that contributes to the frailty directly and indirectly through other intermediate physiologic systems, such as the musculoskeletal, endocrine, and hematologic systems. The complex multifactorial etiologies of frailty also include obesity and other age-related specific diseases. Herein, we investigate the link between chronic inflammation and frailty of the older people. In particular, we present an up-to-date review of the role of cytokines, interleukins, cardiovascular abnormalities, chronic high blood pressure, hyperlipidemia and diabetes in relation to the severity of frailty in the elderly.
衰弱是老年人中预期会出现的身体、认知和心理衰退的自然状态。炎症在衰弱发病机制中的作用已被提出假设，到目前为止，已经进行了许多研究以了解这种关联背后的作用机制。最近的研究支持了这一假设，并表明炎症、衰弱与年龄相关疾病之间存在明显关联。慢性炎症是关键的病理生理过程，它通过其他中间生理系统，如肌肉骨骼、内分泌和血液系统，直接和间接地导致衰弱。衰弱复杂的多因素病因还包括肥胖和其他与年龄相关的特定疾病。在此，我们研究慢性炎症与老年人衰弱之间的联系。特别是，我们对细胞因子、白细胞介素、心血管异常、慢性高血压、高脂血症和糖尿病在老年人衰弱严重程度方面的作用进行了最新综述。
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