Spiezia Luca, Campello Elena, Valle Fabio Dalla, Simion Chiara, Colpo Anna, Simioni Paolo
Department of Medicine, Thrombotic and Hemorrhagic Diseases Unit, University of Padua Medical School, Via Giustiniani, 2, 35128, Padua, Italy.
Ann Hematol. 2018 Jun;97(6):1057-1060. doi: 10.1007/s00277-018-3255-3. Epub 2018 Feb 1.
Post-thrombotic syndrome (PTS) has been associated to DVT recurrence, increased FVIII, inflammatory biomarker plasma levels, and persistence of vein obstruction. These same features have also been widely reported in non-O blood type subjects. Our aim was to investigate the correlation between the incidence of PTS and ABO blood types. Consecutive patients referred to the Department of Medicine of University of Padua between January 2004 and January 2012 following the diagnosis of a first episode of proximal DVT were enrolled. The presence of PTS was assessed via the Villalta scale at predefined time points (3, 6, 12, 18, 24, 36 months). Hazard ratio (HR) for PTS development was calculated in non-O (exposed) vs O blood (unexposed) type patients. Out of 671 eligible patients, 606 were enrolled. Overall, 192 (31.7%) patients developed PTS: 142 (34.5%) non-O and 50 (25.6%) O blood type patients. Individuals with non-O blood group were associated with a significantly higher risk to develop PTS (HR 1.53, 95% CI, 1.05-2.24; p = 0.028) than O group. Non-O blood type might be a risk factor for the development of PTS.
血栓形成后综合征（PTS）与深静脉血栓形成（DVT）复发、因子VIII升高、炎症生物标志物血浆水平以及静脉阻塞持续存在有关。在非O血型受试者中也广泛报道了这些相同的特征。我们的目的是研究PTS发病率与ABO血型之间的相关性。纳入了2004年1月至2012年1月期间因首次诊断为近端DVT而转诊至帕多瓦大学医学系的连续患者。在预定时间点（3、6、12、18、24、36个月）通过Villalta量表评估PTS的存在情况。计算非O型（暴露）与O型血（未暴露）患者发生PTS的风险比（HR）。在671名符合条件的患者中，606名被纳入研究。总体而言，192名（31.7%）患者发生了PTS：142名（34.5%）非O型血和50名（25.6%）O型血患者。非O血型个体发生PTS的风险显著高于O型血个体（HR 1.53，95% CI，1.05 - 2.24；p = 0.028）。非O血型可能是PTS发生的一个危险因素。
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