Sayyahfar Shirin, Davoodzadeh Faranak, Hoseini Rozita, Rahimzadeh Nahid, Otukesh Hasan
Department of Pediatrics, Division of Pediatric Infectious Diseases, Ali Asghar Children Hospital, Research Center of Pediatric Infectious Diseases, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran.
Pediatrician, Iran University of Medical Sciences, Tehran, Iran.
Pediatr Transplant. 2018 Mar;22(2). doi: 10.1111/petr.13148. Epub 2018 Feb 1.
IGRA has been approved as an alternative in vitro test to diagnose Mycobacterium TB infection. This study aimed to assess the diagnostic value of TST in comparison with QFT assay to detect LTBI among Iranian children candidate for renal transplantation. This cross-sectional study was performed on 31 children who were candidate for renal transplantation admitted to Ali Asghar Children's Hospital and Rasoul Akram Hospital, Tehran, Iran, from 2013 to 2014. TST and QFT were performed for all patients. QFT was negative in all patients, while TST was positive only in one case. Both tests results were negative in 30 patients, yielding an accuracy rate of 96.7% for TST to diagnose LTBI when compared to QFT. In conclusion, compared to QFT, TST is still a valuable diagnostic tool with high accuracy rate for diagnosis of LTBI in children candidates for renal transplantation and can still be used as an accurate test for screening Mycobacterium TB infection.
干扰素-γ释放试验（IGRA）已被批准作为诊断结核分枝杆菌感染的一种体外替代检测方法。本研究旨在评估结核菌素皮肤试验（TST）与全血γ干扰素释放试验（QFT）在检测伊朗肾移植候选儿童潜伏性结核感染（LTBI）方面的诊断价值。这项横断面研究于2013年至2014年对伊朗德黑兰阿里·阿斯加尔儿童医院和拉苏勒·阿克拉姆医院收治的31例肾移植候选儿童进行。对所有患者均进行了TST和QFT检测。所有患者的QFT结果均为阴性，而TST仅1例呈阳性。30例患者的两项检测结果均为阴性，与QFT相比，TST诊断LTBI的准确率为96.7%。总之，与QFT相比，TST仍然是诊断肾移植候选儿童LTBI的一种有价值的诊断工具，准确率高，仍可作为筛查结核分枝杆菌感染的准确检测方法。
