Research Center of Pediatric Infectious Diseases, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran.
Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
Transpl Infect Dis. 2020 Jun;22(3):e13268. doi: 10.1111/tid.13268. Epub 2020 Mar 6.
Currently, tuberculin skin test (TST) and interferon gamma release assay (IGRA) are used to find the latent tuberculosis infection (LTBI) cases in the candidates of heart transplantation. Therefore, this study aimed to compare TST and IGRA to diagnose LTBI in pediatric heart transplant candidates.
This cross-sectional study was performed on 50 children, who were candidates for heart transplantation, of whom 42 cases underwent heart transplantation in Shahid Rajaie Cardiovascular, Medical, and Research center, Tehran, Iran, from 2016 to 2017.
Participants of the study included 24 male patients (%48) (p-value = 0.67). The mean age of the patients was 8.18 ± 4.27 years (1-16 years). According to the results, IGRA was negative in all patients, and no indeterminate result was reported, while the purified derivative test (PPD) was positive in three (6%) cases. In comparison with QFT, an accuracy of 94% was achieved for TST to diagnose Mycobacterium tuberculosis infection.
It seems that TST can still be used as an accurate test for screening LTBI in pediatric candidates for heart transplantation.
目前，结核菌素皮肤试验（TST）和干扰素-γ释放试验（IGRA）用于发现心脏移植候选者中的潜伏性结核感染（LTBI）病例。因此，本研究旨在比较 TST 和 IGRA 以诊断儿科心脏移植候选者中的 LTBI。
这是一项横断面研究，共纳入 50 名儿童，他们均为心脏移植候选者，其中 42 例于 2016 年至 2017 年在伊朗德黑兰的 Shahid Rajaie 心血管医学和研究中心接受了心脏移植。
研究参与者包括 24 名男性患者（48%）（p 值=0.67）。患者的平均年龄为 8.18±4.27 岁（1-16 岁）。结果显示，所有患者的 IGRA 均为阴性，无不确定结果报告，而纯化蛋白衍生物试验（PPD）在 3 例（6%）患者中呈阳性。与 QFT 相比，TST 诊断结核分枝杆菌感染的准确性为 94%。
TST 似乎仍可用于筛查儿科心脏移植候选者中的 LTBI。
