a Department of Orthopaedic Surgery , Bispebjerg Hospital, University of Copenhagen.
b Department of Clinical Biochemistry , Bispebjerg Hospital, University of Copenhagen , Denmark.
Acta Orthop. 2018 Apr;89(2):170-176. doi: 10.1080/17453674.2018.1428436. Epub 2018 Feb 1.
Background and purpose - While development in hip fracture incidence and mortality is well examined, none has yet looked at the temporal trends regarding prevalence of co-morbidities. Therefore we investigated changes in incidence of first hip fracture, co-morbidity prevalence, 30 day- and 1-year mortality in hip fracture patients in the Danish population during the period 1999 to 2012. Patients and methods - Patients >18 years admitted with a fractured hip in Denmark between 1996 and 2012 were identified with data for the period 1999-2012 being analyzed regarding prevalence of co-morbidities, incidence, and mortality. Results - 122,923 patients were identified. Incidence in the whole population declined but sex-specific analysis showed no changes for men. For the whole study population, 30-day and 1-year mortality remained unchanged. Age at time of first hip fracture also remained unchanged. Of the included co-morbidities a decrease in prevalence of malignancy and dementia in women was found while there was an increase in the prevalence of all remaining co-morbidities, except hemi- or paraplegia for both sexes, rheumatic diseases for women, and for men diabetes with complications, myocardial infarction, AIDS/HIV, and malignancy. Interpretation - While hip fracture incidence declined for women it was unchanged for men; likewise, 30-day and 1-year mortality rates together with age at first fracture remained unchanged. When these results are compared with the relatively large increase in the prevalence of co-morbidities, it does not seem likely that the increased disease burden is affecting either the incidence or the mortality.
背景与目的 - 虽然髋部骨折的发病率和死亡率的发展情况已经得到很好的研究,但目前还没有研究关于合并症患病率的时间趋势。因此,我们调查了在 1999 年至 2012 年期间,丹麦人群中首次髋部骨折的发病率、合并症患病率、30 天和 1 年死亡率的变化。
患者和方法 - 1996 年至 2012 年期间,丹麦因髋部骨折住院的>18 岁患者被确定为研究对象,对 1999 年至 2012 年期间的合并症患病率、发病率和死亡率进行了分析。
结果 - 共确定了 122923 名患者。全人群的发病率下降,但男性的发病率分析显示没有变化。对于整个研究人群,30 天和 1 年死亡率保持不变。首次髋部骨折时的年龄也保持不变。在所包括的合并症中,女性恶性肿瘤和痴呆的患病率下降,而除两性偏瘫或截瘫、女性风湿性疾病以及男性糖尿病并发症、心肌梗死、艾滋病/艾滋病、恶性肿瘤外,所有其他合并症的患病率均有所增加。
结论 - 虽然女性髋部骨折的发病率下降,但男性髋部骨折的发病率不变;同样,30 天和 1 年的死亡率以及首次骨折时的年龄也保持不变。当将这些结果与合并症患病率的大幅增加进行比较时,似乎增加的疾病负担不会影响发病率或死亡率。