小 GTPase RAB37 作为自噬体生物发生的组织者发挥作用。
The small GTPase RAB37 functions as an organizer for autophagosome biogenesis.
机构信息
a Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences , Wuhan University , Wuhan , China.
出版信息
Autophagy. 2018;14(4):727-729. doi: 10.1080/15548627.2018.1434374. Epub 2018 Mar 13.
Abstract
Macroautophagy/autophagy is a catabolic process that is essential for cellular homeostasis. How autophagosomal vesicle forms in a spatio-temporally regulated manner remains elusive. Our recent study revealed that small GTPase, RAB37 (RAB37, member RAS oncogene family), functions as a key organizer of autophagosomal membrane biogenesis. RAB37 interacts with ATG5 (autophagy related 5) and promotes autophagosome formation by modulating ATG12-ATG5-ATG16L1 complex assembly. These findings provide new insights into autophagy regulation.
摘要
自噬是一种分解代谢过程，对细胞内稳态至关重要。自噬体囊泡如何以时空调节的方式形成仍然难以捉摸。我们最近的研究表明，小分子 GTPase RAB37（RAB37，RAS 癌基因家族成员）是自噬体膜生物发生的关键组织者。RAB37 与 ATG5（自噬相关蛋白 5）相互作用，并通过调节 ATG12-ATG5-ATG16L1 复合物的组装来促进自噬体的形成。这些发现为自噬调节提供了新的见解。
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