Department of General Surgery, The Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Donghu District, Nanchang 330006, China.
Biomolecules. 2024 Jan 30;14(2):161. doi: 10.3390/biom14020161.
Gastric cancer is ranked as the fifth most prevalent cancer globally and has long been a topic of passionate discussion among numerous individuals. However, the incidence of gastric cancer in society has not decreased, but instead has shown a gradual increase in recent years. For more than a decade, the treatment effect of gastric cancer has not been significantly improved. This is attributed to the heterogeneity of cancer, which makes popular targeted therapies ineffective. Methionine is an essential amino acid, and many studies have shown that it is involved in the development of gastric cancer. Our study aimed to review the literature on methionine and gastric cancer, describing its mechanism of action to show that tumor heterogeneity in gastric cancer does not hinder the effectiveness of methionine-restricted therapies. This research also aimed to provide insight into the inhibition of gastric cancer through metabolic reprogramming with methionine-restricted therapies, thereby demonstrating their potential as adjuvant treatments for gastric cancer.
胃癌在全球范围内排名第五，长期以来一直是许多人热议的话题。然而，胃癌在社会中的发病率并没有降低，反而近年来呈逐渐上升趋势。十多年来，胃癌的治疗效果并没有显著改善。这归因于癌症的异质性，使得流行的靶向治疗无效。蛋氨酸是一种必需氨基酸，许多研究表明它参与了胃癌的发展。我们的研究旨在综述蛋氨酸与胃癌的文献，描述其作用机制，表明胃癌中的肿瘤异质性并不妨碍蛋氨酸限制疗法的有效性。这项研究还旨在通过蛋氨酸限制疗法的代谢重编程来抑制胃癌，从而证明它们作为胃癌辅助治疗的潜力。
