Broekhuyse R M, Winkens H J, Kuhlmann E D
Curr Eye Res. 1986 Mar;5(3):231-40. doi: 10.3109/02713688609020048.
Microgram quantities bovine IRBP (interphotoreceptor retinoid binding protein) injected in Freund's complete adjuvant induced severe autoimmune uveoretinitis and pinealitis in Lewis rats. At low doses the onset was accelerated and intensified by co-injection of Hemophilus pertussis bacteria. Wistar, BN and PVG rats were less susceptible, while the eyes of athymic, nude rats did not respond. The disease developed similar to but faster than S-antigen-induced uveoretinitis, while its onset was one day earlier and the reactions were slightly more severe. As distinct from these two types of uveoretinitis, opsin (in much higher doses) caused milder reactions in the anterior segment, while retinitis dominated. In each type of inflammation the photoreceptor cell layer was totally destroyed. All three ocular diseases were inhibited by cyclosporine treatment, which indicates that T cell-dependent mechanisms are essential for the development.
在弗氏完全佐剂中注射微克量的牛视网膜间维生素A结合蛋白（IRBP）可在Lewis大鼠中诱发严重的自身免疫性葡萄膜视网膜炎和松果体炎。在低剂量时，通过共同注射百日咳杆菌可加速发病并加重病情。Wistar、BN和PVG大鼠较不易感，而无胸腺裸鼠的眼睛则无反应。该疾病的发展与S抗原诱导的葡萄膜视网膜炎相似但更快，其发病提前一天，反应稍严重。与这两种葡萄膜视网膜炎不同的是，视蛋白（剂量高得多）在前房中引起的反应较轻，而视网膜病变占主导。在每种炎症类型中，光感受器细胞层均被完全破坏。所有三种眼部疾病都可通过环孢素治疗得到抑制，这表明T细胞依赖性机制对疾病发展至关重要。
