de Vries C P, Gooren L J, van der Veen E A
Horm Metab Res. 1986 Mar;18(3):203-5. doi: 10.1055/s-2007-1012271.
This study investigated the effects of long-term cyproterone-acetate (CA) treatment on the hypothalamus-pituitary-adrenal axis and further on the release of prolactin and growth hormone. Thirty-one male-to-female transsexuals, treated at least 3 months either with 100 mg CA alone or in combination with 50 micrograms ethinyloestradiol (EO)/day, were studied. In all of them the cortisol response to 250 micrograms Synacthen administration was comparable to that measured in controls. Six subjects treated with CA alone (group I) and six subjects treated with CA + EO (group II) underwent an insulin-hypoglycemia test. Seven eugonadal men served as controls. Compared with control values: in two subjects of group I and one subject of group II a low cortisol response was found. The mean growth hormone response was found to be lower in both groups, whereas the mean prolactin response was lower in group I.
本研究调查了长期醋酸环丙孕酮（CA）治疗对下丘脑 - 垂体 - 肾上腺轴以及进一步对催乳素和生长激素释放的影响。研究了31名男变女的变性者，他们至少3个月来单独使用100 mg CA或与50微克乙炔雌二醇（EO）/天联合使用进行治疗。在所有这些人中，对给予250微克合成促肾上腺皮质激素的皮质醇反应与对照组中测得的反应相当。6名单独接受CA治疗的受试者（I组）和6名接受CA + EO治疗的受试者（II组）进行了胰岛素低血糖试验。7名性腺功能正常的男性作为对照。与对照值相比：在I组的2名受试者和II组的1名受试者中发现皮质醇反应较低。发现两组的平均生长激素反应均较低，而I组的平均催乳素反应较低。
