Mărginean Cristina Oana, Meliţ Lorena Elena, Dobreanu Minodora, Mărginean Maria Oana
Department of Pediatrics I, University of Medicine and Pharmacy Tirgu Mureş, Romania Department of Laboratory Medicine, University of Medicine and Pharmacy Tirgu Mureş, Romania.
Medicine (Baltimore). 2017 Dec;96(51):e8864. doi: 10.1097/MD.0000000000008864.
Hypertriglyceridemia is defined as a level of triglycerides above 150 mg/dL. The complex causes and classification of hypertriglyceridemia lead to difficulties in the diagnosis and management of this condition.
We present the case of a 15 years and 6 months old female teenager, admitted in our clinic for the following complaints: severe abdominal pain predominantly in the lateral left quadrant, nausea, vomiting, and the lack of stools for 2 days. The clinical exam showed: impaired general status, painful abdomen at superficial and deep palpation in the left and upper abdominal quadrants, the absence of stools for 2 days.
The laboratory parameters revealed leukocytosis with neutrophilia, thrombocytopenia, high level of serum amylase and triglycerides, and increased inflammatory biomarkers. The imagistic investigations showed ascites and paralytic ileus.
The management was burdened by the side-effects of hypolipidemic drugs impairing the liver function and leading to rhabdomyolysis, but eventually the patient's outcome was good.
Type V hyperlipoproteinemia is a rare condition accounting for approximately 5% of the cases. The risk for acute pancreatitis is well-known to be associated with hypertriglyceridemia, even though in rare cases.
The prognosis of hypertriglyceridemia is pediatrics is burdened not only by the long-term risk factors associated to the diseases itself, but also by the negative effects of long-term hypolipidemic treatment.
高甘油三酯血症的定义为甘油三酯水平高于150毫克/分升。高甘油三酯血症的病因复杂且分类多样，导致该病症的诊断和管理存在困难。
我们报告一例15岁6个月的女性青少年病例，因以下症状入住我院：主要位于左下腹外侧的严重腹痛、恶心、呕吐以及2天未解大便。临床检查显示：一般状况不佳，左腹和上腹部触诊浅部和深部均有压痛，2天未解大便。
实验室检查参数显示白细胞增多伴中性粒细胞增多、血小板减少、血清淀粉酶和甘油三酯水平升高以及炎症生物标志物升高。影像学检查显示有腹水和麻痹性肠梗阻。
降脂药物的副作用给治疗带来负担，这些副作用损害肝功能并导致横纹肌溶解，但最终患者预后良好。
V型高脂蛋白血症是一种罕见病症，约占病例的5%。众所周知，急性胰腺炎的风险与高甘油三酯血症相关，尽管这种情况很少见。
小儿高甘油三酯血症的预后不仅受到与疾病本身相关的长期风险因素的影响，还受到长期降脂治疗的负面影响。
