1 University of Virginia, USA.
2 Massachusetts General Hospital, USA.
Autism. 2019 Feb;23(2):468-476. doi: 10.1177/1362361318755318. Epub 2018 Feb 1.
The newest edition of the Diagnostic and Statistical Manual of Mental Disorders (5th ed., DSM-5) introduced substantial changes to the diagnostic criteria for autism spectrum disorder, including new severity level ratings for social communication and restricted and repetitive behavior domains. The purpose of this study was to evaluate the use of these new severity ratings and to examine their relation to other measures of severity and clinical features. Participants included 248 children with autism spectrum disorder who received diagnostic evaluations at one of six Autism Treatment Network sites. Higher severity ratings in both domains were associated with younger age, lower intelligence quotient, and greater Autism Diagnostic Observation Schedule-Second Edition domain-specific symptom severity. Greater restricted and repetitive behavior severity was associated with higher parent-reported stereotyped behaviors. Severity ratings were not associated with emotional or behavioral problems. The new DSM-5 severity ratings in both domains were significantly associated with behavioral observations of autism severity but not with measures of other behavioral or emotional symptoms. However, the strong associations between intelligence quotient and DSM-5 severity ratings in both domains suggest that clinicians may be including cognitive functioning in their overall determination of severity. Further research is needed to examine clinician decision-making and interpretation of these specifiers.
《精神障碍诊断与统计手册》(第五版,DSM-5)最新版对自闭症谱系障碍的诊断标准进行了重大修改,包括社交沟通和受限及重复行为领域的新严重程度分级。本研究旨在评估这些新严重程度分级的使用情况,并研究它们与其他严重程度和临床特征测量的关系。研究参与者包括 248 名在六个自闭症治疗网络站点之一接受诊断评估的自闭症谱系障碍儿童。两个领域的严重程度评分越高,年龄越小,智商越低,第二版自闭症诊断观察量表特定领域的症状严重程度越高。更严重的受限和重复行为与更高的家长报告刻板行为有关。严重程度评分与情绪或行为问题无关。两个领域的新 DSM-5 严重程度评分与自闭症严重程度的行为观察显著相关,但与其他行为或情绪症状的测量无关。然而,智商和两个领域的 DSM-5 严重程度评分之间的强烈关联表明,临床医生可能将认知功能纳入其严重程度的整体评估中。需要进一步研究以检查临床医生的决策和对这些特定症状的解释。