蒽环类药物米托蒽醌与育亨宾在晚期L 12010和P 388白血病中存在超相加协同作用。
Overadditive synergism between the intercalators mitoxantrone and lucanthone in advanced L 12010 and P 388 leukemia.
作者信息
Osswald H, Youssef M
出版信息
J Cancer Res Clin Oncol. 1986;111(2):137-40. doi: 10.1007/BF00400752.
Abstract
The combination of mitoxantrone with lucanthone, a schistosomicidal and nonmyelotoxic agent, yielded a therapeutic synergism in L 1210 and P 388 leukemia with no increase in toxicity. In that combination the nonmyelotoxic lucanthone enabled the use of the optimal dose of mitoxantrone. The recent hypothesis that planar polycyclic aromatic compounds, mostly comprised by the term intercalators, intercalate with DNA or bind to DNA may need receiving with respect to membrane target sites.
摘要
米托蒽醌与一种杀血吸虫且无骨髓毒性的药物卢坎酮联合使用，在L 1210和P 388白血病中产生了治疗协同作用，且毒性未增加。在这种联合用药中，无骨髓毒性的卢坎酮使得能够使用米托蒽醌的最佳剂量。最近关于平面多环芳香化合物（大多由嵌入剂这一术语涵盖）嵌入DNA或与DNA结合的假说，可能需要从膜靶点的角度来审视。
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