抗癌药物阿霉素在不进入细胞的情况下也可具有细胞毒性。
The anticancer agent adriamycin can be actively cytotoxic without entering cells.
作者信息
Triton T R, Yee G
出版信息
Science. 1982 Jul 16;217(4556):248-50. doi: 10.1126/science.7089561.
PMID:7089561
Abstract
The antineoplastic agent adriamycin was coupled to an insoluble agarose support. This material was actively cytotoxic to L1210 cells in culture under conditions in which no free adriamycin could enter the cell. It is concluded that an agent whose principal target was previously thought to be DNA can exert its cytotoxic action solely by interaction at the cell surface.
摘要
抗肿瘤药物阿霉素与一种不溶性琼脂糖载体偶联。在无游离阿霉素进入细胞的条件下，这种材料对培养中的L1210细胞具有显著的细胞毒性。得出的结论是，一种其主要靶点以前被认为是DNA的药物可以仅通过在细胞表面的相互作用发挥其细胞毒性作用。
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